Results 41 to 50 of about 152,318 (298)
A pH Switch for β‐Sheet Protein Folding [PDF]
Angewandte Chemie, 2017 AbstractProtein design advancements have led to biotechnological strategies based on more stable and more specific structures. Herein we present a 6‐residue sequence (HPATGK) that acts as a stable structure‐nucleating turn at physiological and higher pH but is notably unfavorable for chain direction reversal at low pH.
Jordan M. Anderson, Niels H. Andersen
openaire +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Unraveling metamaterial properties in zigzag-base folded sheets
Science Advances, 2015 Zigzag-base mechanical metamaterials have the outstanding properties of Miura-ori and expand on its design space.
Eidini, Maryam, Paulino, Glaucio H.
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Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Systematic validation of protein force fields against experimental data. [PDF]
PLoS ONE, 2012 Molecular dynamics simulations provide a vehicle for capturing the structures, motions, and interactions of biological macromolecules in full atomic detail.
Kresten Lindorff-Larsen +5 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Florida Foliage House Plant Care: Adenium swazicum
EDIS, 2014 Adenium swazicum is a species of desert rose whose gray-green leaves appear folded and are velvety to touch. It is sought after by collectors for its graceful, weeping branches and delicate flowers that occur in various shades of pink.
Richard J. Henny, Jianjun Chen
doaj +5 more sources
Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding. [PDF]
PLoS Computational Biology, 2015 Many proteins comprising of complex topologies require molecular chaperones to achieve their unique three-dimensional folded structure. The E.coli chaperone, GroEL binds with a large number of unfolded and partially folded proteins, to facilitate proper ...
Suhani Nagpal +3 more
doaj +1 more source
Planning to fold multiple objects from a single self-folding sheet [PDF]
Robotica, 2011 SUMMARYThis paper considers planning and control algorithms that enable a programmable sheet to realize different shapes by autonomous folding. Prior work on self-reconfiguring machines has considered modular systems in which independent units coordinate with their neighbors to realize a desired shape.
An, Byoung Kwon +3 more
openaire +3 more sources