Results 171 to 180 of about 391,837 (318)

Determinants of Protein Folding Pathways: Lessons from Metamorphic Proteins. [PDF]

Int J Mol Sci
Pennacchietti V, Di Felice M, Toso J, Caldarelli L, Ventura ES, Malagrinò F, Toto A, Gianni S.   +7 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Membrane Protein Folding and Biogenesis: Insights from Single-Molecule Force Spectroscopy. [PDF]

Chem Rev
Kim SA, Kim S, Nam J, Kim E, Yoon TY, Min D.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Structure-Based Simulations for Folding of a tRNA Isodecoder. [PDF]

Molecules
Levintov L, Orellana EA, Vashisth H.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Realistic Protein Folding with Next Generation Methodology and Supercomputer

, 2010
Protein folding is the hot and focus research field in computational biology and HPC. The major factors affect protein folding are interaction energy function, conformational sampling and computer resource.
李国辉
core  

Coordinated expression and assembly of BiP, p58^IPK, and ER chaperone complexes maximize proinsulin folding in pancreatic β cells. [PDF]

Proc Natl Acad Sci U S A
Jang I, Duffey A, Itkin-Ansari P, Arvan P, Kaufman RJ.   +4 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Long-term effects of preterm birth on cortical folding trajectories in early childhood. [PDF]

Brain Commun
Jang YH, Kim JM, Lee BG, Hoh JK, Lee GY, Kim HH, Lyu I, Lee HJ.   +7 more
europepmc   +1 more source