Results 31 to 40 of about 15,380 (223)

Establishment of Patient-Derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsies

Gut and Liver, 2022
Background/Aims: Three-dimensional cultures of human pancreatic cancer tissue also known as “organoids” have largely been developed from surgical specimens.
Jee Hyung Lee, Haeryoung Kim, Sang Hyub Lee, Ja-Lok Ku, Jung Won Chun, Ha Young Seo, Soon Chan Kim, Woo Hyun Paik, Ji Kon Ryu, Sang Kook Lee, Andrew M. Lowy, Yong-Tae Kim   +11 more
doaj   +1 more source

Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review [PDF]

, 2018
Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with ...
Biankin, Andrew V., Khachigian, Levon M., Parish, Christopher R., Sheahan, Anjali V.   +3 more
core   +1 more source

Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Acland, Assenat, Bazhin, Carbone, Chaput, Chen, Chouaib, Danenberg, David, Dyson, El-Deiry, Gallick, Gelovani, Ghansah, Giese, Gil, Gress, Gribben, Hao, Hao, Hao, Henson, Jemal, Kiessling, Kroemer, Kroemer, Kroemer, Levi, Luo, Mi, Moses, Plate, Powis, Powis, Powis, Ravichandran, Ricci, Rodeck, Sarker, Schuler, Semenza, Singh, Spisek, Tani, Vandenabeele, Wang, Wang, Zitvogel, Zitvogel, Zitvogel   +49 more
core   +1 more source

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

Survival Benefit Associated With Resection of Locally Advanced Pancreatic Cancer After Upfront FOLFIRINOX Versus FOLFIRINOX Only

Annals of Surgery, 2021
Objective: This study compared median OS after resection of LAPC after upfront FOLFIRINOX versus a propensity-score matched cohort of LAPC patients treated with FOLFIRINOX-only (ie, without resection). Background: Because the introduction of FOLFIRINOX chemotherapy, increased ...
Brada, L.J.H., Daamen, L.A., Magermans, L.G., Walma, M.S., Latifi, D., van Dam, R.M., de Hingh, I.H.J.T., Liem, M.S., de Meijer, V.E., Patijn, G.A., Festen, S., Stommel, M.W.J., Stommel, M.W.J., Bosscha, K., Polée, M.B., Nio, Y.C., Wessels, F.J., de Vries, J.J.J., van Lienden, K.P., Bruijnen, R.C., Busch, O.R., Koerkamp, B.Groot, van Eijck, C., Molenaar, Q.I., Wilmink, H.J.W., van Santvoort, H.C., Besselink, M.G.H.   +26 more
openaire   +7 more sources

Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma

OncoImmunology, 2018
Pancreatic adenocarcinoma (PAC) has a poor prognosis. One treatment approach, investigated here, is to reinforce antitumor immunity. Dendritic cells (DCs) are essential for the development and regulation of adaptive host immune responses against tumors ...
Aurélie Collignon, Françoise Silvy, Stéphane Robert, Malika Trad, Sébastien Germain, Jérémy Nigri, Frédéric André, Véronique Rigot, Richard Tomasini, Bernard Bonnotte, Dominique Lombardo, Eric Mas, Evelyne Beraud   +12 more
doaj   +1 more source

FOLFIRINOX Induction Therapy for Stage 3 Pancreatic Adenocarcinoma [PDF]

Annals of Surgical Oncology, 2015
Reports show that FOLFIRINOX therapy for pancreatic ductal adenocarcinoma (PDAC) results in objective response rates two to threefold higher than those of other regimens. This study aimed to assess response and resection rates for locally unresectable (stage 3) patients initially treated with induction FOLFIRINOX.The institutional cancer database was ...
Eran, Sadot, Alexandre, Doussot, Eileen M, O'Reilly, Maeve A, Lowery, Karyn A, Goodman, Richard Kinh Gian, Do, Laura H, Tang, Mithat, Gönen, Michael I, D'Angelica, Ronald P, DeMatteo, T Peter, Kingham, William R, Jarnagin, Peter J, Allen   +12 more
openaire   +2 more sources

Hepatic Arterial Infusion Chemotherapy With Folfirinox or Oxaliplatin Alone in Metastatic Colorectal Cancer

Frontiers in Medicine, 2022
BackgroundHepatic arterial infusion (HAI) of chemotherapy is an option for the treatment of patients with liver metastases from colorectal cancer (LMCRC).
Violaine Randrian, Simon Pernot, Baptiste Sionneau, Denis Smith, Annie Lim, Yann Touchefeu, Claire Gallois, Anthony Turpin, Sahir Javed, Rosine Guimbaud, Pascale Rivera, Mehdi Karoui, Edouard Auclin, Edouard Auclin, Julien Taieb   +14 more
doaj   +1 more source

Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis [PDF]

, 2014
Background Advanced pancreatic cancer confers poor prognosis and treatment advancement has been slow. Recent randomized clinical trials (RCTs) have demonstrated survival benefits for combination therapy compared to gemcitabine alone ...
Gillian K Gresham, George A Wells, Sharlene Gill, Christopher Cameron, Derek J Jonker   +4 more
core   +1 more source

LncRNA SNHG7 Regulates Mesenchymal Stem Cell Through the Notch1/Jagged1/Hes-1 Signaling Pathway and Influences Folfirinox Resistance in Pancreatic Cancer

Frontiers in Oncology, 2021
Pancreatic cancer (PC) is one of the deadliest gastrointestinal cancers, accounting for the fourth highest number of cancer-related fatalities. Increasing data suggests that mesenchymal stem cells (MSCs) might influence the drug resistance of GC cells in
Dongfeng Cheng, Juanjuan Fan, Kai Qin, Yiran Zhou, Jingrui Yang, Yang Ma, Minmin Shi, Minmin Shi, Jiabin Jin   +8 more
doaj   +1 more source