Results 41 to 50 of about 15,380 (223)

Palliative chemotherapy for pancreatic adenocarcinoma: a retrospective cohort analysis of efficacy and toxicity of the FOLFIRINOX regimen focusing on the older patient [PDF]

, 2017
Background: Pancreatic cancer occurs more frequently in older patients, but these are underrepresented in the phase III clinical studies that established the current treatment standards. This leads to uncertainty regarding the treatment of older patients
Berger, Anne Katrin, Byl, Anne, Ehmann, Martin, Haag, Georg Martin, Jäger, Dirk, Springfeld, Christoph   +5 more
core   +1 more source

[Comment] Brazil-TNT : a randomized phase 2 trial of neoadjuvant chemoradiation followed by FOLFIRINOX versus chemoradiation for stage Ⅱ/Ⅲ rectal cancer

结直肠肛门外科
[Background] Neoadjuvant radiation and oxaliplatin-based systemic therapy (total neoadjuvant therapy, TNT) have been shown to increase response and organ-preservation rates in localized rectal cancer.
Li Laiyuan, Yang Xiongfei
doaj   +1 more source

Current status on the place of FOLFIRINOX in metastatic pancreatic cancer and future directions

Therapeutic Advances in Gastroenterology, 2017
Pancreatic cancer (PC) incidence rates are rapidly increasing in developed countries, with half the patients being metastatic at diagnosis. For decades, fluorouracil, then gemcitabine regimens were the preferred palliative first-line options for fit ...
Aurélien Lambert, Céline Gavoille, Thierry Conroy   +2 more
doaj   +1 more source

Treatment patterns and cost estimations of systemic chemotherapy for pancreatic cancer in Japan: A retrospective database study

Cancer Medicine, 2023
Background This study aimed to clarify the treatment patterns of pancreatic cancer patients receiving systemic chemotherapy in Japan and to estimate the direct medical costs in actual practice.
Yuki Takumoto, Ryotaro Shibahara, Hajime Asami, Manabu Akazawa   +3 more
doaj   +1 more source

Intensified neoadjuvant chemotherapy with nab-paclitaxel plus gemcitabine followed by FOLFIRINOX in a patient with locally advanced unresectable pancreatic cancer [PDF]

, 2014
The prognosis of patients with locally advanced pancreatic cancer can be improved if secondary complete (R0) resection is possible. In patients initially staged as unresectable this may be achieved with neoadjuvant treatment which is usually ...
Bluemel, Christina, Hartlapp, Ingo, Herrmann, Ken, Kapp, Markus, Kunzmann, Volker, Steger, Ulrich   +5 more
core   +2 more sources

FOLFIRINOX for advanced pancreatic cancer: the Princess Margaret Cancer Centre experience [PDF]

British Journal of Cancer, 2016
FOLFIRINOX has been shown to significantly increase both overall survival (OS) and progression-free survival (PFS) in metastatic pancreas cancer. There is limited data regarding the treatment of locally advanced pancreatic cancer. We present a retrospective study of patients with both locally advanced and metastatic pancreas cancer using FOLFIRINOX as ...
Chllamma, Muralidharan K., Cook, Natalie, Dhani, Neesha C., Giby, Kazim, Dodd, Anna, Wang, Lisa, Hedley, David W., Moore, Malcolm J., Knox, Jennifer J.   +8 more
openaire   +4 more sources

Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer [PDF]

, 2019
Matrix metalloproteinase 9 (MMP9) is involved in the proteolysis of extracellular proteins and plays a critical role in pancreatic ductal adenocarcinoma (PDAC) progression, invasion and metastasis.
Awasthi, Niranjan, Mikels‐Vigdal, Amanda J., Monahan, Sheena, Schwarz, Margaret A., Schwarz, Roderich E., Smith, Victoria, Stefanutti, Erin   +6 more
core   +1 more source

Diverse avenues of research support the transmethylation theory of psychosis: implications for neuroprotection

Exploration of Neuroprotective Therapy
Transmethylation in the context of psychiatry has historically referred to the enzymatic transfer of a methyl group from one biochemical to another, whose resulting function can change so dramatically that a biochemical like tryptamine, for example, is ...
Christine L. Miller
doaj   +1 more source

Excellent Response to Olaparib in a Patient with Metastatic Pancreatic Adenocarcinoma with Germline BRCA1 Mutation after Progression on FOLFIRINOX: Case Report and Literature Review

Case Reports in Oncology, 2020
Metastatic pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Until recently, cytotoxic chemotherapy was the only treatment option. Currently, there are subgroups of patients with PDAC either with somatic or germline mutations who are ...
Jefferson Rios Pimenta, Serli Kiyomi Nakao Ueda, Renata D’Alpino Peixoto   +2 more
doaj   +1 more source

FOLFIRINOX after first-line gemcitabine-based chemotherapy in advanced pancreatic cancer: a retrospective comparison with FOLFOX and FOLFIRI schedules

Therapeutic Advances in Medical Oncology, 2020
Background: Pancreatic adenocarcinoma is the fourth leading cause of cancer-related death. In cases with metastasis, the combination of 5-fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or gemcitabine-based chemotherapy regimens are considered the
Francesca Foschini, Fabiana Napolitano, Alberto Servetto, Roberta Marciano, Eleonora Mozzillo, Anna Chiara Carratù, Antonio Santaniello, Pietro De Placido, Priscilla Cascetta, Giovanni Butturini, Isabella Frigerio, Paolo Regi, Nicola Silvestris, Sabina Delcuratolo, Enrico Vasile, Caterina Vivaldi, Cataldo Bianco, Sabino De Placido, Luigi Formisano, Roberto Bianco   +19 more
doaj   +1 more source