Results 141 to 150 of about 14,325,085 (286)

Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop. [PDF]

Virchows Arch, 2023
Ondrejka SL, Amador C, Climent F, Ng SB, Soma L, Zamo A, Dirnhofer S, Quintanilla-Martinez L, Wotherspoon A, Leoncini L, de Leval L.   +10 more
europepmc   +1 more source

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease [PDF]

T follicular helper (Tfh) cells play a central role in humoral autoimmunity, including primary Sjögren disease (SjD). However, targeting Tfh cells in clinical management is challenging.
Wu, Meiling, Chen, Yacun, Zeng, Weizhen, Xie, Jing, Lin, Xiang, Shen, Jiangang, Li, Philip Hei, Yu, Sulan, Fu, Weiwei, Feng, Yun   +9 more
core   +1 more source

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

Cell Reports
Summary: SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees.
Masanori Isogawa, Masahiro Shinoda, Ryutaro Kotaki, Kazutaka Terahara, Taishi Onodera, Kiyomi Kabasawa, Mio Toyama-Kousaka, Mizuki Fujisawa, Mitsukaze Watanabe, Keisuke Tonouchi, Tommy Terooatea, Ayumi Kitano, Yu Adachi, Saya Moriyama, Tomohiro Takano, Shuetsu Fukushi, Takayuki Matsumura, Kazuo Yamashita, Masaharu Shinkai, Yoshimasa Takahashi   +19 more
doaj   +1 more source

Aberrant expansion of follicular helper T cell subsets in patients with systemic lupus erythematosus. [PDF]

Front Immunol, 2022
Jin X, Chen J, Wu J, Lu Y, Li B, Fu W, Wang W, Cui D.   +7 more
europepmc   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

American Journal of Hematology, EarlyView.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas, Nichola Cooper, Vickie McDonald, Karina Yazdanbakhsh, Wilma Barcellini   +4 more
wiley   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Follicular B helper T cells in antibody responses and autoimmunity

, 2015
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer.
Garcia De Vinuesa, Maria Carola, Mackay, Charles R, Moser, Bernhard, Tangye, Stuart G   +3 more
core   +1 more source

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

Heliyon
Helper T cells are traditionally classified into T helper 1 (TH1) and T helper 2 (TH2). The more recent discoveries of T helper 17 (TH17), follicular helper T cells (TFH) and regulatory T cells (Treg) enhanced our understanding on the mechanisms of ...
Andy Ka Chun Kan, Wang Tik Tang, Philip H. Li   +2 more
doaj   +1 more source

Evolution of antigen-specific follicular helper T cell transcription from effector function to memory. [PDF]

Sci Immunol, 2022
Robinson AM, Higgins BW, Shuparski AG, Miller KB, McHeyzer-Williams LJ, McHeyzer-Williams MG.   +5 more
europepmc   +1 more source