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Human biomarker navigator

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The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

A successful in vitro fertilization outcome in a hermaphrodite male

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 424-425, April 2025.
Shima Elbakhit M. E. Albasha, Sami Saadi Al‐Said, Haitham Tharwat M. H. El Bardisi   +2 more
wiley   +1 more source

IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment

Cancer Cell, 2023
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME).
Andrew Elia, Julie Leca, Jérôme Fortin   +2 more
exaly   +2 more sources

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T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Nature Reviews Rheumatology, 2019
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells. TFH cells are instrumental in supporting antibody affinity
Jun Deng, Yunbo Wei, Válter R. Fonseca, Luis Graca, Di Yu   +4 more
openaire   +5 more sources

Follicular helper T cells in rheumatoid arthritis

Clinical Rheumatology, 2015
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in the joints and other tissues. Rheumatoid factor (RF) and anticyclic citrullinated peptides (anti-CCP) are biomarkers for the evaluation of RA although their functions in the pathogenesis of RA are poorly understood.
Meixing, Yu, Vanesssa, Cavero, Qiao, Lu, Hong, Li   +3 more
openaire   +2 more sources

T follicular helper cells in autoimmune diseases

Journal of Autoimmunity, 2023
T follicular helper (Tfh) cells with the phenotype of mainly expressing surface molecules C-X-C motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting cytokine interleukin-21 (IL-21) and requiring the transcription factor B cell lymphoma 6 (BCL-6) have been recently defined as a new subset of CD4+ T cells.
Xindi Wei, Xiaoyin Niu
openaire   +2 more sources

Follicular T helper cells and cutaneous T-cell lymphomas

British Journal of Dermatology, 2022
Abstract Linked Article:  Wang et al. Br J Dermatol 2022; 187:970–980.
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Revealing T follicular helper cells with BCL6

Nature Reviews Immunology, 2021
Shane Crotty discusses three independent studies published in 2009 that characterized T follicular helper cells as a distinct subset of CD4+ T cells on the basis of selective expression of BCL6.
openaire   +2 more sources

Noncanonical functions of T follicular helper cells

Science Immunology
T follicular helper cells (T FH cells) are essential for germinal center (GC) formation and maintenance. However, recent insights reveal that T FH cells play additional immune regulatory roles beyond their traditional B cell helper function.
Shivangi Dave, André Ballesteros-Tato
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T follicular helper cells in space-time

Nature Reviews Immunology, 2016
T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce long-lived, high-affinity plasma cells and memory B cells ...
openaire   +2 more sources