Results 61 to 70 of about 19,954 (207)

Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]

, 2010
Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Dimitris Anastassiou, Hoon Kim, John Watkinson, Vinay Varadan   +3 more
core   +1 more source

Localization of inhibins and activins in normal endocrine cells and endocrine tumors of the gut and pancreas: an immunohistochemical and in situ hybridization study [PDF]

, 2004
Activins and inhibins, which belong to the TGF beta family, are composed of different combinations of alpha-, betaA-, and betaB-subunits, resulting in inhibin A (alphabetaA), inhibin B (alphabetaB), activin A (betaAbetaA), activin B (betaBbetaB), and ...
Capella, C, La Rosa, S, Lloyd, Rv, Marchet, S, Uccella, S.   +4 more
core   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, EarlyView.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice.

PLoS ONE, 2019
With rapid economic development, the prevalence of obesity has increased remarkably worldwide. Obesity can induce a variety of metabolic diseases, such as atherosclerosis, diabetes, hypertension and coronary heart disease, which significantly endanger ...
Haoyu Li, Chuanhai Zhang, Junyu Liu, Wenya Xie, Wentao Xu, Fei Liang, Kunlun Huang, Xiaoyun He   +7 more
doaj   +1 more source

Comparison of bioactivities, binding properties and intra-follicular levels of bovine follistatins [PDF]

, 2015
Five isoforms of follistatin (FST) (Mr 31, 33, 35, 37, 41kDa) were purified from bovine follicular fluid (bFF). Comparison of their activin- and heparan sulphate proteoglycan (HSP)-binding properties and bio-potencies in neutralization of activin-A ...
Boland, Maurice P., Glister, Claire, Ireland, James J., Knight, Phil G., Sunderland, Simon J.   +4 more
core   +1 more source

Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits.
Guilherme Oselame, Suelen Fernandes Padilha, Maurício Egídio Cantão, Jane de Oliveira Peixoto, Aline Zampar, Adriana Mércia Guaratini Ibelli, Luis Orlando Duitama Carreño, Jader Silva Lopes, Pedro Henrique Ferreira Freitas, Marcelo Silva Freitas, Mônica Corrêa Ledur   +10 more
wiley   +1 more source

Differential Expression and Release of Activin A and Follistatin in Chronic Rhinosinusitis with and without Nasal Polyps.

PLoS ONE, 2015
BackgroundChronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP) should be regarded as distinct clinical entities based on differential inflammatory mediator and remodeling profiles.
Yucheng Yang, Nan Zhang, Koen Van Crombruggen, Feng Lan, Guohua Hu, Suling Hong, Claus Bachert   +6 more
doaj   +1 more source

Cellular and Molecular Responses Unique to Major Injury Are Dispensable for Planarian Regeneration [PDF]

, 2019
The fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, positional information, and a set of cellular and molecular responses collectively called the “missing
Oderberg, Isaac Max, Reddien, Peter, Stern, Sarah R., Tewari, Aneesha Gandhi   +3 more
core   +1 more source

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV‐induced skin damage

Photochemistry and Photobiology, Volume 101, Issue 2, Page 338-349, March/April 2025.
In the present work with mouse models, we demonstrate that a novel compound, NEO400, is able to profoundly protect skin against damage caused by UV radiation (UVR) when it is applied to skin post‐UVR exposure. In comparison, Aloe vera or linoleic acid are unable to achieve a similar level of protection.
Stephen Swenson, Catalina Silva‐Hirschberg, Liliana Freeland, Kristen L. Chen, Nagore I. Marín‐Ramos, Axel H. Schönthal, Thomas C. Chen   +6 more
wiley   +1 more source

Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal Study

The Journal of Nutrition, Health and Aging
Objectives: The link between aging and pulmonary function decline is well-established, but the underlying mechanisms have yet to be fully revealed. Serum follistatin, a myokine implicated in muscle degeneration, may play a role in age-related pulmonary ...
Hsiao-Chin Shen, Wei-Ju Lee, Chuan-Yen Sun, Wen-Kuang Yu, Wei-Chih Chen, Fei-Yuan Hsiao, Kuang-Yao Yang, Liang-Kung Chen   +7 more
doaj   +1 more source