Results 71 to 80 of about 13,850 (204)

Activin and follistatin in female reproduction

Molecular and Cellular Endocrinology, 2004
Activin and follistatin were initially identified in the follicular fluid based on their effects on pituitary FSH secretion in the mid-1980s. It is now evident that activin, follistatin and activin receptors are widely expressed in many tissues where they function as autocrine/paracrine regulators of a variety of physiological processes including ...
Muttukrishna, S, Tannetta, D, Groome, N, Sargent, I   +3 more
openaire   +2 more sources

Follistatin-Related Protein and Follistatin Differentially Neutralize Endogenous vs. Exogenous Activin [PDF]

Endocrinology, 2002
Follistatin-related protein (FSRP) is a new addition to the expanding follistatin (FS)-related gene family whose members contain at least one conserved 10-cysteine follistatin domain. In contrast to other members of this family, FSRP and follistatin also share a common exon/intron domain structure, substantial primary sequence homology, and an ability ...
Yisrael, Sidis, Drew V, Tortoriello, William E, Holmes, Yang, Pan, Henry T, Keutmann, Alan L, Schneyer   +5 more
openaire   +2 more sources

Characterization of a recombinant porcine follistatin in a heat shock expression system

, 2002
The role of follistatin in ovarian function has yet to be fully elucidated; it is present in low concentration in vivo and it is difficult to obtain suitable quantities of follistatin for characterization.
P. J. Chedrese, V. Misra, M. J. Redmond, C. R. Christensen, J. Kowalski, B. Laarveld   +5 more
core   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring

Frontiers in Immunology, 2020
Ascending bacterial pyelonephritis, a form of urinary tract infection (UTI) that can result in hospitalization, sepsis, and other complications, occurs in ~250,000 US patients annually; uropathogenic Escherichia coli (UPEC) cause a large majority of ...
Teri N. Hreha, Christina A. Collins, Allyssa L. Daugherty, Jessie M. Griffith, Keith A. Hruska, Keith A. Hruska, David A. Hunstad, David A. Hunstad   +7 more
doaj   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Heparin-mediated dimerization of follistatin

Experimental Biology and Medicine, 2020
Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-β (TGFβ) family ligand antagonist, follistatin 288 (FS288).
Ryan G Walker, Chandramohan Kattamuri, Erich J Goebel, Fuming Zhang, Michal Hammel, John A Tainer, Robert J Linhardt, Thomas B Thompson   +7 more
openaire   +5 more sources

Low follistatin level is a causal risk factor for spontaneous abortion: a two-sample mendelian randomization study

Frontiers in Endocrinology
BackgroundRecurrent pregnancy loss is a distressing event during pregnancy, and understanding its causal factors is crucial. Follistatin, a glycoprotein involved in folliculogenesis and embryogenesis, has been implicated as a potential contributor to the
Chen Gong, Chen Gong, Chen Gong, Chen Gong, Wenzhi Yang, Xue Liu, Xinliang Li, Yutong Wang, Yutong Wang, Yutong Wang, Yutong Wang, Chan Tian, Chan Tian, Chan Tian, Chan Tian, Chan Tian   +15 more
doaj   +1 more source

MCP‐1 From Aging Dermal Adipose Tissue Impairs Hair Follicle Cycling via Macrophage Recruitment: Implications for Age‐Related Alopecia

Aging Cell, Volume 25, Issue 11, November 2026.
Aging orchestrates a dWAT–MCP‐1–CCR2 axis that recruits and reprograms macrophage subpopulations, disrupting the local M1/M2 balance and suppressing WNT signaling, thereby impairing both hair cycle transition and production of genes associated with melanogenesis.
Jian Chen, Yuhui Hou, Ke Ye, Yilong Guo, Pingping Sun, Fangfang Qi, Zhexiang Fan, Damao Dai, Xiaomin Liu, Shulian Wu, Demengjie Le, Zhiqi Hu, Yong Miao, Qian Qu   +13 more
wiley   +1 more source

Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin

Reproductive Biology and Endocrinology, 2018
Background TGF-β signaling pathways regulate several crucial processes in female reproduction. AKT is a non-SMAD signaling pathway regulated by TGF-β ligands essential for oocyte maturation and early embryonic development in the mouse, but its regulatory
Mohamed Ashry, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott, Nabil A. Hemeida, Omaima M. Kandil, Refaat S. Ragab, George W. Smith   +7 more
doaj   +1 more source