Results 71 to 80 of about 9,676 (180)

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Activin/follistatin system in grass carp pituitary cells: - Regulation by local release of growth hormone and luteinizing hormone and its functional role in growth hormone synthesis and secretion.

PLoS ONE, 2017
Gonadotrophin regulation by activin/follistatin system is well-documented, but the corresponding effect on growth hormone (GH) has not been fully characterized and with little information available in lower vertebrates, especially in fish models.
Roger S K Fung, Jin Bai, Karen W Y Yuen, Anderson O L Wong   +3 more
doaj   +1 more source

The Impact of Collection Protocol on the Yield and Purity of Mesenchymal Stem Cell‐Derived Extracellular Vesicles Isolated From Serum‐Free Media

Biotechnology Journal, Volume 21, Issue 7, July 2026.
Graphical Abstract and Lay Summary Mesenchymal stem cells (MSCs) were cultured in standard, ultracentrifuged (UC), or starvation serum‐free media to evaluate how medium influences extracellular vesicle (EV) yield and purity. Culture in UC medium improved EV purity but reduced yield.
Jolene Phelps, Sara Hassanpour Tamrin, Neil A. Duncan, Arindom Sen   +3 more
wiley   +1 more source

Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Obesity is increasingly recognised as an important factor contributing to cancer progression, particularly in breast cancer. However, the cellular and molecular mechanisms underlying obesity‐driven breast cancer remain unclear. Several theories have been proposed to explain the complex interactions between adipose tissue and cancer ...
Charlise Basson, Michael S. Pepper, Anna M. Joubert, Melvin A. Ambele   +3 more
wiley   +1 more source

Mesenchymal Stem Cell‐Based Therapy for Cerebellar Ataxia: From Bench to Bedside

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Allogeneic hMSCs transplanted across LPS, Ara‐C, and SCA2 cerebellar ataxia (CA) models suppress neuroinflammation and restore the neurotrophin axis, collectively preserving Purkinje cell integrity. These preclinical findings are being translated clinically, from a first‐in‐human case report to an ongoing Phase II/III randomized trial (NCT02540655 ...
Kyoungho Suk, Ho‐Won Lee, Sang Ryong Kim   +2 more
wiley   +1 more source

Postbiotics: An Overview and Recommendations for Improved Reporting

Molecular Nutrition &Food Research, Volume 70, Issue 14, 29 July 2026.
Human clinical trials of postbiotics and corresponding preclinical evidence were evaluated. Key reporting gaps identified included inconsistent terminology, incomplete inactivation method reporting, variable dosing information, insufficient quality‐control data, and inadequate taxonomic characterization.
Mehreen Anjum, Arthur C. Ouwehand
wiley   +1 more source

Inhibition of mesoderm formation by follistatin

Development Genes and Evolution, 1998
Mesoderm induction requires interaction between cells of the animal and vegetal hemispheres of the embryo. Several molecules have been proposed as candidates for mesoderm-inducing signals, with activin a particularly strong candidate. However, it has not been possible to inhibit mesoderm formation in vivo by specifically blocking activin action ...
Marchant, Lorena, Linker, Claudia, Mayor, Roberto   +2 more
openaire   +3 more sources

Activin Signaling Inhibitors in Pulmonary Hypertension: A State‐of‐the‐Art Review

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a disease of abnormal pulmonary vascular remodeling and vascular obliteration that results in right heart failure and death. PAH pathogenesis is strongly associated with mutations of the Transforming Growth Factor Beta (TGF‐β) superfamily signaling pathway, which has previously been challenging to ...
Sudarshan Rajagopal, Joseph Abueg, Kevin M. Hart, Edmund Lau, Eliana C. Martinez, Nicholas W. Morrell, Ioana R. Preston, Sandeep Sahay, Namita Sood, Paul B. Yu, Nayeli G. Zayas‐Hernández   +10 more
wiley   +1 more source

The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio

Frontiers in Physiology, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Alexandra Baccam, Alexandra Baccam, Alexandra Baccam, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Marco Rocchi, Viviana Moresi, Viviana Moresi, Marilia Seelaender, Zhenlin Li, Sergio Adamo, Sergio Adamo, Zhigang Xue, Dario Coletti, Dario Coletti, Dario Coletti   +16 more
doaj   +1 more source

A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

eLife, 2019
The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the
Meenakshi Prajapati-DiNubila, Ana Benito-Gonzalez, Erin Jennifer Golden, Shuran Zhang, Angelika Doetzlhofer   +4 more
doaj   +1 more source