Results 61 to 70 of about 9,676 (180)

Impaired Follistatin Secretion in Cirrhosis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2016
Abstract Context: Follistatin is a liver-derived inhibitor of the muscle-growth inhibitor myostatin. Reduction in acute follistatin release may help explain muscle loss in liver cirrhosis. Objective: The study aimed to investigate the
Rinnov, Anders Rasmussen, Plomgaard, Peter, Pedersen, Bente Klarlund, Gluud, Lise Lotte   +3 more
openaire   +3 more sources

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho, Min‐Kyung Choi, Mi‐Ock Baek, Hyeon‐Hee Son, Binh Thanh Nguyen, Min‐Jung Kang, Il‐Chan Kim, Jin‐Hyoung Kim, Mee‐Sup Yoon   +8 more
wiley   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma [PDF]

European Journal of Endocrinology, 2004
OBJECTIVE: Activin A is a multifunctional growth and cell differentiation factor produced by normal endometrium, and secreted in high amounts by endometrial adenocarcinoma. In the present study we evaluated the expression of two inhibitory activin A ligands, follistatin and follistatin-related gene (FLRG), in endometrial adenocarcinoma and in age ...
Ciarmela, Pasquapina, Florio, Pasquale, SiguroardÃ3ttir, Matthildur, Toti, Paolo, Maguer-Satta, Veronique, Rimokh, Ruth, Altomare, Aldo, Tosi, Piero, Petraglia, Felice   +8 more
openaire   +3 more sources

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, Volume 269, Issue 4-5, Page 433-445, August 2026.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin

Reproductive Biology and Endocrinology, 2018
Background TGF-β signaling pathways regulate several crucial processes in female reproduction. AKT is a non-SMAD signaling pathway regulated by TGF-β ligands essential for oocyte maturation and early embryonic development in the mouse, but its regulatory
Mohamed Ashry, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott, Nabil A. Hemeida, Omaima M. Kandil, Refaat S. Ragab, George W. Smith   +7 more
doaj   +1 more source

A Myocyte‐Enriched Long Non‐Coding RNA NRMLncR Enhances Myogenesis in Mouse

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
We identified a novel myocyte‐enriched, Notch‐repressed myogenic lncRNA, NRMLncR, that is induced by myogenic regulatory factors (MRFs) during myogenic progression in mouse. NRMLncR localizes to cytoplasmic and nuclear compartments, associates with the RNA‐binding protein CUGBP Elav‐like family member 1 (CELF1), and is linked to neighboring gene Tbx1 ...
Yufen Li, Yumei Zhou, Qing Ying Li, Justine Arrington, Zhengzheng Hu, Mostafa F. Abdelhai, Yubo Wang, Junxiao Ren, Yung‐Yu Cheng, Mingyi Xie, W. Andy Tao, Shihuan Kuang, Feng Yue   +12 more
wiley   +1 more source

Low follistatin level is a causal risk factor for spontaneous abortion: a two-sample mendelian randomization study

Frontiers in Endocrinology
BackgroundRecurrent pregnancy loss is a distressing event during pregnancy, and understanding its causal factors is crucial. Follistatin, a glycoprotein involved in folliculogenesis and embryogenesis, has been implicated as a potential contributor to the
Chen Gong, Chen Gong, Chen Gong, Chen Gong, Wenzhi Yang, Xue Liu, Xinliang Li, Yutong Wang, Yutong Wang, Yutong Wang, Yutong Wang, Chan Tian, Chan Tian, Chan Tian, Chan Tian, Chan Tian   +15 more
doaj   +1 more source

Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring

Frontiers in Immunology, 2020
Ascending bacterial pyelonephritis, a form of urinary tract infection (UTI) that can result in hospitalization, sepsis, and other complications, occurs in ~250,000 US patients annually; uropathogenic Escherichia coli (UPEC) cause a large majority of ...
Teri N. Hreha, Christina A. Collins, Allyssa L. Daugherty, Jessie M. Griffith, Keith A. Hruska, Keith A. Hruska, David A. Hunstad, David A. Hunstad   +7 more
doaj   +1 more source

Heparin-mediated dimerization of follistatin

Experimental Biology and Medicine, 2020
Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-β (TGFβ) family ligand antagonist, follistatin 288 (FS288).
Ryan G Walker, Chandramohan Kattamuri, Erich J Goebel, Fuming Zhang, Michal Hammel, John A Tainer, Robert J Linhardt, Thomas B Thompson   +7 more
openaire   +5 more sources