Results 51 to 60 of about 9,676 (180)

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone

Skeletal Muscle, 2018
Background Myostatin antagonists are being developed as therapies for Duchenne muscular dystrophy due to their strong hypertrophic effects on skeletal muscle.
Andrea Iskenderian, Nan Liu, Qingwei Deng, Yan Huang, Chuan Shen, Kathleen Palmieri, Robert Crooker, Dianna Lundberg, Niksa Kastrapeli, Brian Pescatore, Alla Romashko, John Dumas, Robert Comeau, Angela Norton, Jing Pan, Haojing Rong, Katayoun Derakhchan, David E. Ehmann   +17 more
doaj   +1 more source

Follistatin and the Breast Implant Capsule

Plastic and Reconstructive Surgery - Global Open, 2017
Background: Breast capsular contracture remains an elusive problem faced by plastic surgeons and is the leading long-term complication after breast implantation. Follistatin (Fst) is a protein with known anti-inflammatory and antifibrotic properties and has the potential to limit the severity of diseases associated with ...
Frenkiel, Brett A., Temple-Smith, Peter, de Kretser, David, Southwick, Graeme J.   +3 more
openaire   +2 more sources

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Differential Expression and Release of Activin A and Follistatin in Chronic Rhinosinusitis with and without Nasal Polyps.

PLoS ONE, 2015
BackgroundChronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP) should be regarded as distinct clinical entities based on differential inflammatory mediator and remodeling profiles.
Yucheng Yang, Nan Zhang, Koen Van Crombruggen, Feng Lan, Guohua Hu, Suling Hong, Claus Bachert   +6 more
doaj   +1 more source

Association Between EAT‐Lancet Diet Adherence and Sleep Quality in Lactating Women: A Cross‐Sectional Analysis

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims In recent years, the sustainable EAT‐Lancet diet (ELD) has garnered attention for its health benefits, especially regarding mental health and cognitive function. However, its impact on sleep health remains underexplored. This study aims to investigate the relationship between ELD and sleep quality, focusing on lactating ...
Farzam Kamrani, Shima Jafari, Samira Karbasi, Zahra Khorasanchi   +3 more
wiley   +1 more source

Pegylated Interferon-α Modulates Liver Concentrations of Activin-A and Its Related Proteins in Normal Wistar Rat

Mediators of Inflammation, 2015
Aims. To measure the expression of activin βA-subunit, activin IIA and IIB receptors, Smad4, Smad7, and follistatin in the liver and the liver and serum concentrations of mature activin-A and follistatin in normal rat following treatment with pegylated ...
Bassem Refaat, Adel Galal El-Shemi, Ahmed Mohamed Ashshi, Elaf Wael Mahamid, Noha Mohammed Al-Qadi   +4 more
doaj   +1 more source

Follistatin as an Inhibitor of Experimental Metastasis [PDF]

Clinical Cancer Research, 2008
Activin, a member of the transforming growth factor-β (TGF-β) superfamily, and its antagonist, follistatin, can regulate cell proliferation, differentiation, angiogenesis, apoptosis, and potentially tumor growth.
openaire   +2 more sources

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source

Activin and follistatin in female reproduction

Molecular and Cellular Endocrinology, 2004
Activin and follistatin were initially identified in the follicular fluid based on their effects on pituitary FSH secretion in the mid-1980s. It is now evident that activin, follistatin and activin receptors are widely expressed in many tissues where they function as autocrine/paracrine regulators of a variety of physiological processes including ...
Muttukrishna, S, Tannetta, D, Groome, N, Sargent, I   +3 more
openaire   +2 more sources