Results 71 to 80 of about 19,954 (207)
The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts
Arthritis Research & Therapy, 2019 Background Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA).
Magnus Diller +11 more
doaj +1 more source
Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins [PDF]
, 2005 © The Company of Biologists Ltd 2005Paracrine factors secreted by the oocyte regulate a broad range of cumulus cell functions. Characteristically, cumulus cells have a low incidence of apoptosis and we proposed that this is due to oocyte-secreted factors
Amato, F. +4 more
core +2 more sources
Advanced Science, Volume 13, Issue 8, 9 February 2026.FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu +12 more
wiley +1 more source
Skeletal Muscle, 2018 Background Myostatin antagonists are being developed as therapies for Duchenne muscular dystrophy due to their strong hypertrophic effects on skeletal muscle.
Andrea Iskenderian +17 more
doaj +1 more source
Activin/TGFβ and BMP crosstalk determines digit chondrogenesis [PDF]
, 2008 The progress zone (PZ) is a specialized area at the distal margin of the developing limb where mesodermal cells are kept in proliferation and undifferentiated, allowing limb outgrowth.
1000010205429 +5 more
core +11 more sources
Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała +3 more
wiley +1 more source
Physiological Fluid Flow Moderates Fibroblast Responses to TGF-β1. [PDF]
, 2016 Fibroblasts are the major cellular component of connective tissue and experience mechanical perturbations due to matrix remodelling and interstitial fluid movement.
Ahluwalia +30 more
core +1 more source
Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Alan Fappi +10 more
wiley +1 more source
Mediators of Inflammation, 2015 Aims. To measure the expression of activin βA-subunit, activin IIA and IIB receptors, Smad4, Smad7, and follistatin in the liver and the liver and serum concentrations of mature activin-A and follistatin in normal rat following treatment with pegylated ...
Bassem Refaat +4 more
doaj +1 more source
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]
, 2013 Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor +75 more
core +2 more sources