Results 51 to 60 of about 4,249 (125)

Effect of liver abnormalities on mortality in Fontan patients: a systematic review and meta-analysis

BMC Cardiovascular Disorders
Background Fontan-associated liver disease (FALD) is one of the most common complications following Fontan procedure, but the impact of FALD on survival outcomes remains controversial.
Xiang Liu, Linjiang Han, Ziqin Zhou, Jiazichao Tu, Jianrui Ma, Jimei Chen   +5 more
doaj   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Shear wave dispersion to assess liver disease progression in Fontan-associated liver disease.

PLoS ONE, 2022
AimWe aimed to analyze the dispersion slope (DS) using shear wave dispersion (SWD) in patients with Fontan-associated liver disease (FALD) and to investigate its utility as a biomarker of disease progression.MethodsThis cross-sectional study enrolled 27 ...
Tomoaki Nagasawa, Hidekatsu Kuroda, Tamami Abe, Hirofumi Saiki, Yasuhiro Takikawa   +4 more
doaj   +1 more source

The physiology of thoracic duct pressure and flow: A review of the literature

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract The thoracic duct (TD) is the largest vessel of the lymphatic system, transporting interstitial fluid, macromolecules, and immune cells into the venous circulation via the lymphovenous junction. Respiratory and circulatory forces have been proposed as key drivers of TD lymph propulsion; however, the literature reports inconsistent findings ...
Sara Moazzam, Lomani A. O'Hagan, Alys R. Clarke, Peter S. Russell, Anthony R. J. Phillips, John A. Windsor, S. Ali Mirjalili   +6 more
wiley   +1 more source

Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Pulmonary vascular disease in patients with single ventricular heart disease is a significant source of morbidity and mortality. Utilizing an integrated investigative platform that included a novel ovine Glenn model, we demonstrate early pulmonary vascular endothelial dysfunction with the initiation of the nonpulsatile pulmonary blood flow that ...
Jonathan Hyde, Michael A. Smith, Naveen Swami, John H. Hwang, Yenchun Chao, Jason Boehme, Gary W. Raff, Casper Noah Nilsson, Wenhui Gong, Gail H. Deutsch, Eric G. Johnson, Ting Wang, Stephen M. Black, Sanjeev A. Datar, Emin Maltepe, Jeffrey R. Fineman   +15 more
wiley   +1 more source

Hepatic Fibrosis Is Universal Following Fontan Operation, and Severity is Associated With Time From Surgery: A Liver Biopsy and Hemodynamic Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Congestive hepatopathy is a recognized complication of Fontan physiology. Data regarding the incidence of hepatopathy and risk factors are lacking.
David J. Goldberg, Lea F. Surrey, Andrew C. Glatz, Kathryn Dodds, Michael L. O'Byrne, Henry C. Lin, Mark Fogel, Jonathan J. Rome, Elizabeth B. Rand, Pierre Russo, Jack Rychik   +10 more
doaj   +1 more source

An Otolaryngology‐Focused Risk Stratification for Postoperative Dysphagia in Pediatric Cardiac Surgery

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 6, December 2025.
ABSTRACT Objectives To develop and validate a risk stratification model for postoperative dysphagia in pediatric cardiac surgery patients, focusing on factors relevant to otolaryngologic assessment and implications for Otolaryngology management. Methods Analysis of 174 pediatric patients undergoing cardiac surgery at a tertiary care center between ...
Matthew Zhang, Basir Mansoor, Marlaine Frelier, Cynthia Wang, Yann‐Fuu Kou, Stephen R Chorney, Romaine Johnson   +6 more
wiley   +1 more source

Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation

JACC: Advances
Background: The Fontan operation is associated with chronic venous hypertension, liver and renal disease, and several other sequelae. The alterative surgical approach, when feasible, a biventricular conversion (BiV), may diminish some of these long-term ...
Muhammad Bakr Ghbeis, MD, Caroline Pane, BS, Rebecca Beroukhim, MD, Eric Feins, MD, Pedro J. del Nido, MD, Lynn A. Sleeper, ScD, Sitaram E. Emani, MD, John N. Kheir, MD   +7 more
doaj   +1 more source

Hepatic Venous Pressure Gradient in Fontan Physiology Has Limited Diagnostic and Prognostic Significance

CJC Open, 2020
Background: Hepatic venous pressure gradient (HVPG) is measure of portal pressure and a prognostic tool in patients with viral and alcoholic cirrhosis; its utility is unknown in patients with Fontan-associated liver disease (FALD).
Alexander C. Egbe, MD, MPH, William R. Miranda, MD, Gruschen R. Veldtman, MD, Rondell P. Graham, MBBS, Patrick S. Kamath, MD   +4 more
doaj   +1 more source

Assessment of Double Outlet Left Ventricle in Pediatrics Using Transthoracic Echocardiography and Computed Tomographic Angiography

Pediatric Discovery, Volume 3, Issue 4, December 2025.
The clinical manifestation of DOLV was atypical. TTE has a relatively high diagnostic accuracy for DOLV in pediatric, which is very valuable for its early detection. ABSTRACT Double outlet left ventricle (DOLV) is a rare congenital cardiac anomaly in which both great arteries originate entirely or predominantly from the morphologic left ventricle.
Xu Zhu, Guangyi Zhong, Xiaojuan Ji, Xue Xiang, Min Zheng, Huina Yan, Rui Li   +6 more
wiley   +1 more source