Results 91 to 100 of about 1,444,729 (311)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

When eating becomes business

RAE: Revista de Administração de Empresas, 2018
A alimentação é um grande negócio no Brasil e em todo o mundo. A empresa brasileira 3G Capital, por exemplo, foi notícia por sua aquisição de marcas internacionais renomadas como Budweiser, Kraft-Heinz e Burger King. A liderança gerencial atual do Brasil
Marina Heck, Jeffrey Pilcher, Krishnendu Ray, Eliane Brito   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Culturally appropriate food in local food systems and associated health impacts among immigrants living in high-income countries

Journal of Agriculture, Food Systems, and Community Development
While health research typically centers on nutri­tional value and clinical health outcomes, research on food (in)security among immigrants emphasizes the crucial need for culturally appropriate food, necessitating a holistic approach that accounts for ...
Luyue Zheng, Ge Ge, Shuhan Wen, Analena Bruce   +3 more
doaj   +3 more sources

Understanding Korean food culture from Korean paintings

Journal of Ethnic Foods, 2016
Background: In Korea, there are many traditional foods that have developed along with the country's rich history. In addition, various food cultures have developed through agricultural traditions, ritual ceremonies, and the sharing of affection ...
Hae Kyung Chung, Kyung Rhan Chung, Hung Ju Kim   +2 more
doaj   +1 more source

The different dimensions of livelihood impacts of Payments for Environmentals Services (PES) schemes: A systematic review [PDF]

, 2018
Through a systematic review of peer-reviewed and grey literature, this paper analyzes evidence of the livelihood impacts of Payments for Environmental Services (PES). Forty-six studies assessed PES livelihood impacts.
Bax, Vincent, Blundo Canto, Genowefa, Cruz-Garcia, Gisella S., Groeneveld, Rolf A., Perez-Marulanda, Lisset, Quintero, Marcela   +5 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Healthier the Tastier? USA-India Comparison Studies on Consumer Perception of a Nutritious Agricultural Product at Different Food Processing Levels

Frontiers in Public Health, 2016
Present research compares food beliefs associated with a naturally nutritious agricultural commodity (namely pulses) in Western and Eastern cultures (namely US and India). Specifically, this paper focuses on the perception of healthiness and tastefulness
Laurette eDube, Hajar eFatemi, Ji eLu, Cristian eHertzer   +3 more
doaj   +1 more source

Best Before: Recipes and Food in Contemporary Aboriginal Art [PDF]

, 2011
This thesis consists of a curatorial essay and contemporary art exhibition entitled Best Before featuring artwork by KC Adams, Keesic Douglas, Cheryl L’Hirondelle, Peter Morin and Suzanne Morrissette.
Rose Myers, Lisa
core