Computer-Aided (In Silico) Modeling of Cytochrome P450-Mediated Food-Drug Interactions (FDI). [PDF]
Int J Mol Sci, 2022 Modifications of the activity of Cytochrome 450 (CYP) enzymes by compounds in food might impair medical treatments. These CYP-mediated food–drug interactions (FDI) play a major role in drug clearance in the intestine and liver. Inter-individual variation
Guttman Y, Kerem Z.
europepmc +3 more sources
Knowledge of Food-Drug Interactions among Medical University Students. [PDF]
NutrientsBackground: Food–drug interactions (FDIs) may alter drug pharmacokinetics and pharmacodynamics, modifying the whole therapy’s effectiveness. Some of them cause the attenuation of drug effects, while others inhibit the medicines’ metabolism resulting, in ...
Jelińska M +5 more
europepmc +3 more sources
Adverse food–drug interactions [PDF]
Regulatory Toxicology and Pharmacology, 2015 Food supplements and herbal products are increasingly popular amongst consumers. This leads to increased risks of interactions between prescribed drugs and these products containing bioactive ingredients. From 1991 up to 2014, 55 cases of suspected adverse drug reactions due to concomitant intake of health-enhancing products and drugs were reported to ...
de Boer, A., van Hunsel, F, Bast, Aalt
openaire +4 more sources
PLoS ONE, 2021 Background Foods and the nutrients they contain can interact with drugs and thereby interfere with their therapeutic safety and efficacy. Adequate knowledge of healthcare professionals (HCPs) about drug-food interactions can help in preventing potential ...
Emmanuella Chinonso Osuala +2 more
doaj +4 more sources
FooDrugs: a comprehensive food-drug interactions database with text documents and transcriptional data. [PDF]
Database (Oxford), 2023 Food–drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects of a drug and impact both their efficacy and their ...
Lacruz-Pleguezuelos B +8 more
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Enriching the FIDEO ontology with food-drug interactions from online knowledge sources [PDF]
Journal of Biomedical SemanticsThe increasing number of articles on adverse interactions that may occur when specific foods are consumed with certain drugs makes it difficult to keep up with the latest findings.
Rabia Azzi +4 more
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Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions. [PDF]
Pharmaceutics, 2020 The distribution of drugs and dietary phenolic compounds in the systemic circulation de-pends on, among other factors, unspecific/specific reversible binding to plasma proteins such as human serum albumin (HSA).
López-Yerena A +3 more
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Potential Risk of Food-Drug Interactions: Citrus Polymethoxyflavones and Flavanones as Inhibitors of the Organic Anion Transporting Polypeptides (OATP) 1B1, 1B3, and 2B1. [PDF]
Eur J Drug Metab Pharmacokinet, 2020 Background and Objectives Citrus flavonoids are not only components of daily nutrition, they are also promoted as dietary supplements and are important ingredients in traditional medicines.
Bajraktari-Sylejmani G, Weiss J.
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Food-drug interactions: genotoxicological aspects
Фармакокинетика и Фармакодинамика, 2016 Resume. Reviewed phenomenology of food-drug interactions, pharmacokinetic and other targets of this interaction. The attention is focused on possible genotoxic adverse events by food-drug interactions.
A. D. Durnev
doaj +1 more source
Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling. [PDF]
Int J Mol SciPiperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4. The aim of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model for piperine and to predict potential food–drug interactions ...
Lin F +5 more
europepmc +2 more sources