Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target.
Samuel Kemble +12 more
wiley +1 more source
A drawing by Food Not Bombs co-founder Keith McHenry to illustrate Food Not Bombs gatherings, tours or other actions. This drawing depicts and overhead view of three tables of kitchen supplies and equipment and a lateral and overhead view of three tables
McHenry, Keith, 1957-
core +1 more source
Cyproheptadine enhances weight gain and modulates appetite-regulating peptides in children with failure to thrive and food allergies. [PDF]
Zhang Y +8 more
europepmc +1 more source
Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome
Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani +10 more
wiley +1 more source
The Hidden Burden of Food Hypersensitivity: Exploring Perceived Stress and Fatigue Symptoms in Children with Food Allergies and Intolerances. [PDF]
Martin-Hadmaș RM +3 more
europepmc +1 more source
Expert Perspective: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies
Treat‐to‐target (T2T) has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal T2T framework for adult IIM has not yet been established.
Shiri Keret +2 more
wiley +1 more source
Knowledge, attitudes, and practices toward food allergies among early childhood educators in Taiwan: a cross-sectional study. [PDF]
Lu FT +8 more
europepmc +1 more source
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source
Age-specific early-life gut microbiome associations with eczema and food allergies during early immune development. [PDF]
Nunez H +8 more
europepmc +1 more source

