Results 71 to 80 of about 222,532 (235)

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Advanced Science, EarlyView.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng   +10 more
wiley   +1 more source

Specific IgE Response to Purified and Recombinant Allergens in Latex Allergy [PDF]

, 2005
Background In recent years, allergy to natural rubber latex has emerged as a major allergy among certain occupational groups and patients with underlying diseases.
Arif, Siti AM, Bansal, Naveen K., Breiteneder, Heimo, Elms, Nancy, Fink, Jordan N., Kelly, Kevin J., Kurup, Viswanath P., Sussman, Gordon L., Yeang, Hoong Y.   +8 more
core   +4 more sources

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Advanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang   +10 more
wiley   +1 more source

Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula? [PDF]

, 2011
Background: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied.
Meyer, R, De Koker, C, Dziubak, R, Godwin, H, Dominguez-Ortega, G, Shah, N   +5 more
core   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

How safe is your curry? Food allergy awareness of restaurant staff [PDF]

, 2013
Background: Incidents of severe and fatal anaphylaxis to accidentally ingested food allergens are increasing. Individuals are more likely to encounter difficulties when eating away from home. In restaurants, front-of-house and kitchen staff may be called
Bailey, Sam, Common, Lucy A R, Corrigan, Christopher J, Harris, Scott, Holloway, Judith A, Smith, Helen   +5 more
core   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. [PDF]

, 2016
BACKGROUND: The age at which allergenic foods should be introduced into the diet of breast-fed infants is uncertain. We evaluated whether the early introduction of allergenic foods in the diet of breast-fed infants would protect against the development ...
Ayis, S, Brough, H, Craven, J, EAT Study Team, EAT, Flohr, C, Lack, G, Logan, K, Marrs, T, Peacock, J, Perkin, MR, Radulovic, S, Raji, B, Tseng, A   +12 more
core   +1 more source

Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring

Advanced Electronic Materials, EarlyView.
Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park, Seongyeop Kim, Soojin Lee, Vladimir V. Tsukruk, SeungHyun Park, Hyo‐Ryoung Lim   +5 more
wiley   +1 more source

Effects of Environmental and Health Information on Willingness to Pay for Local and Organic Foods in Taiwan

Agribusiness, EarlyView.
ABSTRACT Using a lab‐in‐the‐field experiment, we investigate how providing information about food miles and pesticide residue influences willingness to pay (WTP) for potatoes among 407 shoppers in Taiwan, split between a supermarket and a farmers market.
Chiu‐Lin Huang, Edward C. Jaenicke, Martina Vecchi, Sheng‐Jang Sheu   +3 more
wiley   +1 more source