Results 231 to 240 of about 64,029 (294)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Quality Analysis and Detection of Adulterants and Contaminations in Milk/Milk Powder by Raman Spectroscopy. [PDF]

Compr Rev Food Sci Food Saf
Acharya BS, Nair S, Abdul Salam AA.
europepmc   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Optimization of Extraction Methods for NMR and LC-MS Metabolite Fingerprint Profiling of Botanical Ingredients in Food and Natural Health Products (NHPs). [PDF]

Molecules
Vinayagam V, Thirugnanasambandam A, Ragupathy S, Sneha R, Newmaster SG.   +4 more
europepmc   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Analysis of Annual Variation in Stable Isotopic Fingerprints of Native Chinese Mitten Crab (<i>Eriocheir sinensis</i>) from Yangcheng Lake. [PDF]

Animals (Basel)
Xue J, Jiang T, Chen X, Yang J, Zhang W.
europepmc   +1 more source

Untargeted lipidomics profiling for halal authentication of meatball products from mixed meat sources. [PDF]

Food Chem X
Harlina PW, Nawaz A, Shahzad R, Amalina NN, Geng F, Rafi M, Maritha V, Pangawikan AD, Rahimah S, Khan MR, Gramita WS, Nurhasya AS.   +11 more
europepmc   +1 more source

Assessing Milk Authenticity Using Protein and Peptide Biomarkers: A Decade of Progress in Species Differentiation and Fraud Detection. [PDF]

Foods
Karamoutsios A, Lekka P, Voidarou CC, Dasenaki M, Thomaidis NS, Skoufos I, Tzora A.   +6 more
europepmc   +1 more source

Effectiveness of Digital Interventions for Low-Income, Food-Insecure Populations: Natural Language Processing Study of WIC Smartphone App User Reviews, 2013-2024.

J Med Internet Res
Lee J.
europepmc   +1 more source

Next-generation sequencing applications in food science: fundamentals and recent advances. [PDF]

Front Bioeng Biotechnol
Tigrero-Vaca J, Díaz B, Gu G, Cevallos-Cevallos JM.   +3 more
europepmc   +1 more source