Results 51 to 60 of about 93,351 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Jurnal Studi Manajemen Organisasi, 2013 Small and medium industry have important role in developing manufacture industries in West Sumatra especially in food sector. Food processing industry in Padang, is potential industry to be developed. Product competitiveness is still lacking in small and
Desi Ariani, Bambang Munas Dwiyanto
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
External Integration on Agri-Food Supply Chain: A review to the state of the art
Ingeniería, 2015 Supply Chain Integration (SCI) has been broadly taken into account due to its strategic importance; however, there are a few agri food supply chain studies.
Andrés Felipe Ruiz Moreno +2 more
doaj
Energies, 2018 In the industrial food supply chain, cold storage is one of the most important processes where there is a huge but still unused potential for employing renewable energy technologies.
Antonella Meneghetti +2 more
doaj +1 more source
Methods for managing the food value chain [PDF]
Управленец, 2019 The paper aims to develop the methods for managing the food value chain at the level of a region and business entities. Methodologically, the study rests on the concept of value chains that takes into account the interests of governing bodies and is ...
Zhanna A. Ermakova +2 more
doaj +1 more source
, 2023 In recent years, our food supply chain facing various disruptions shows a need for higher resilience and sustainability. To better prepare for future uncertainties the food supply chain may encounter, it is imperative to understand the status quo of the ...
Su, I-Hsuan, Hua Tan, Kim, Wu, Lin
core +1 more source
A conceptual understanding of criminality and integrity challenges in food supply chains [PDF]
British Food Journal, 2017 Purpose Business, consumers and governmental organisations are harbouring a growing need to gain an appreciation of behaviours connected to food criminality. In order to acquire a cross-functional understanding of these thematic areas (crime and fraud) the mapping of existing research is needed. The paper aims to discuss these issues.
Liam Fassam, Samir Dani
openaire +2 more sources