Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
'Transparent mice': deep-tissue live imaging using food dyes. [PDF]
Wang F, Zhou C.
europepmc +1 more source
Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li +22 more
wiley +1 more source
The Effect of Hydrogen Peroxide With Different Concentration on the Color and Surface Microhardness of the Resin Bracket. [PDF]
Yang SY.
europepmc +1 more source
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou +7 more
wiley +1 more source
Mangrove cyanobacterial diversity as a source of bioactive natural products. [PDF]
Roy AR +3 more
europepmc +1 more source
Photodynamic Decontamination of Food: Assessing Surface Challenges Against Listeria monocytogenes. [PDF]
Cenit A, Liu J, Fefer M, Plaetzer K.
europepmc +1 more source
Plant-Based Analogs: Potential Chemical Risks & Mitigation Strategies. [PDF]
Arinzechukwu C +3 more
europepmc +1 more source
Microstructure and Release Behavior of Alginate-Natural Hydrocolloid Composites: A Comparative Study. [PDF]
Sıçramaz H +4 more
europepmc +1 more source
Valorization of Fruit and Vegetable Waste: An Approach to Focusing on Extraction of Natural Pigments. [PDF]
Ramzan K +4 more
europepmc +1 more source

