Results 231 to 240 of about 4,449,313 (264)

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Upcycling Apple and Carrot Pomace into Fortified Food Ingredients: Advancing Sustainability and Resource Efficiency. [PDF]

Foods
Căpruciu R, Popescu SM.
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach. [PDF]

World J Microbiol Biotechnol
da Silva MK, da Silva RC, de Souza Melo BM, Cavalcante TJC, da Silva Santos L, E Silva JGP, Maia VRT, da Silva Bernardo M, da Silva Sousa K, da Silva AV, de Oliveira AJ, de Queiroz AC, Rosa LH, Duarte AWF.   +13 more
europepmc   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Carotenoids From Amazonian Fruits as Functional Pigments in Active and Intelligent Food Packaging: Materials, Stability, and Technological Performance. [PDF]

J Food Sci
Devos RJB, Alves LRP, Morais RA, Sousa HMS, Gomes CDC, Sa Peixoto PEP, Martins GAS.   +6 more
europepmc   +1 more source

Slaughter blood-derived bioactive peptides: structure-function relationships, species-specific bioactivities, gastrointestinal stability, and sustainable applications in food systems. [PDF]

Food Sci Anim Resour
Laosam P, Yue Y, Rouabhia M, Suwanangul S, Pinyo J, Katemala S, Paengkoum P, Nakharuthai C, Pongsetkul J, Pongsamai N, Sangsawad P.   +10 more
europepmc   +1 more source

The value-added challenge of nuts: antioxidant components, functions and applications in nut by-products. [PDF]

Front Nutr
Zhou Y, Fan Y, Yang Z, Han X, Li Y, Liu T, Sun N, Chen T, Meng L.   +8 more
europepmc   +1 more source

Phytochemical Profiling (Phenolics and Carotenoids) and Antioxidant Potential of Apple, Plum, Carrot, and Beetroot Juice Pomaces: Towards Sustainable Food Ingredients. [PDF]

Foods
Chiș MS, Fărcaș AC, Martău GA, Vodnar DC, Pop A, Păucean A, Man SM, Andor P.   +7 more
europepmc   +1 more source