Results 61 to 70 of about 3,010,754 (299)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Are food allergic consumers ready for informative precautionary allergen labelling?

Allergy, Asthma & Clinical Immunology, 2017
Precautionary allergen labelling (PAL) has resulted in consumer confusion. Previous research has shown that interpretive labels (using graphics, symbols, or colours) are better understood than the traditional forms of labels.
Giovanni A. Zurzolo, Rachel L. Peters, Jennifer J. Koplin, Maximilian de Courten, Michael L. Mathai, Katrina J. Allen   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Safety of the proposed extension of use of beetroot red (E 162) in foods for special medical purposes in young children

EFSA Journal, 2016
Following a request from the European Commission, the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to provide a scientific opinion on the safety of the extension of use of the food colour beetroot red (E 162) when added
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Yellow and Red Synthetic Food Dyes and Potential Health Hazards: A Mini Review

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology
Synthetic dyes are widely used in the food industry to maintain or restore the colour of food during processing or storage, the azo ones occupying the first place in terms of the extent of use.
Roxana BANC, Lorena FILIP, Anamaria COZMA-PETRUȚ, Daniela CIOBÂRCĂ, Doina MIERE   +4 more
doaj   +1 more source

Safety of the proposed extension of use of synthetic β‐carotene [E 160a(ii)] in foods for special medical purposes in young children

EFSA Journal, 2016
Following a request from the European Commission, the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of the extension of use of the food colour synthetic β‐carotene [E 160a(ii)
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
doaj   +1 more source

Natural food colours.

, 1981
A brief account is given of the development, process details and food applications of natural food colours, nature-identical synthetics, annatto, turmeric, red beet, safflower, paprika, grapes and kokam. The regulatory status of natural colorants is also
Krishnamurthy, N., Sampathu, S. R., Lewis, Y. S., Shivashankar, S., Srinivasa Rao, P. N., Shankaranarayan, R.   +5 more
core  

German database on the occurrence of food additives: application for intake estimation of five food colours for toddlers and children

, 2014
To get a more realistic estimation of food additive intake for toddlers and children, a German database on the occurrence of food additives was created.
Diouf, F., Lindtner, O., Berg, K., Heinemeyer, G., Ptok, S., Heseker, H.   +5 more
core   +1 more source