Results 51 to 60 of about 609,804 (262)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Reasonableness and Spatial Differences of the Food Consumption Structure of Urban and Rural Residents in China, 2015–2021

Foods, 2023
Based on residents’ food consumption data from 31 provinces in China from 2015–2021, this study analyzes the deviation in food consumption from nutrition targets and the spatial distribution characteristics of urban and rural residents in China from 2015–
Yanyan Lian, Lijuan Gu, Linsheng Yang, Li Wang, Hairong Li   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Carbohydrate (CHO) Intake and Quality during Adolescence and Association with HOMA2-IR in Adulthood—The Role of the Chronotype

Proceedings
Background/objectives: Adolescence is associated with two risk markers of Type 2 Diabetes Mellitus (T2DM): insulin resistance and lateness in chronotype. Hence, negative eating behavior during adolescence may increase the future risk of T2DM.
Nicole Jankovic, Bianca Stutz, Bettina Krueger, Christian Herder, Stefan A. Wudy, Anette Buyken, Ute Alexy   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

El consumo alimenticio de la élite hidalga en Galicia durante el siglo XVIII [PDF]

Historia. Instituciones. Documentos, 2012
During the 18th century, the Galician noble elite experienced a magnificent period that was evident in a higher investment in the luxury market relative to the previous centuries. One of their most significant luxury expenses was food.
Antonio Presedo Garazo
doaj  

Neighbourhood fast food exposure and consumption: the mediating role of neighbourhood social norms

International Journal of Behavioral Nutrition and Physical Activity, 2020
Background The association between the residential fast food environment and diet has gained growing attention. However, why the food environment affects food consumption is under-examined.
Sofie van Rongen, Maartje P. Poelman, Lukar Thornton, Gavin Abbott, Meng Lu, Carlijn B. M. Kamphuis, Kirsten Verkooijen, Emely de Vet   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Food consumption changes in South Africa since 1994

South African Journal of Science, 2015
Food consumption patterns in South Africa have changed dramatically over the past decades and likely will continue to change over the coming decades. Various food-related studies conducted over the last few decades indicate that food consumption shifts ...
Lisa-Claire Ronquest-Ross, Nick Vink, Gunnar O. Sigge   +2 more
doaj   +1 more source