Results 91 to 100 of about 4,162,866 (313)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

OKULÖNCESİNDE BESLENME EĞİTİMİ ÜZERİNE BİR ARAŞTIRMA

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2005
Araştırma, beş-altıyaşgrubu çocuklarına verilen beslenme eğitiminin etkisini belirlemek amacıyla, Çanakkale ili Bayramiç ilçesi İlköğretim OkullarıAnasınıflarında yürütülmüştür.
Yasin Ünver, Nurhan Ünüsan
doaj  

Consumers' perception of food traceability in Europe [PDF]

open access: yes
Food traceability has become mandatory since 1st January 2005 in the European Union. Traceability of products and activities in the supply chain has become a new factor of competitiveness in agribusiness and is deemed to be an important criterion of ...
Giraud, Georges, Halawany, Rafia
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Maternal diet in pregnancy and acute leukemia in infants: a case-control study in Mexico City

open access: yesFrontiers in Oncology
IntroductionEpidemiological studies around the world on acute leukemia (AL) and risk factors in infants are scarce. Infant AL has been proposed to originate in utero, which facilitates its study by establishing a short exposure time in pregnant women to ...
María Luisa Pérez-Saldivar   +38 more
doaj   +1 more source

Estimating demand for food commodities by income groups in Indonesia. [PDF]

open access: yes
An analysis of the structure of demand was performed on household data, classified into income groups for urban Indonesia. A demographically augmented Linearized Almost Ideal Demand System was used to estimate the structural parameters of the demand ...
Jensen, Helen, Manrique, Justo
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Comparative advantages and competitiveness of Hungarian and Slovenian agro-food trade in the EU markets [PDF]

open access: yes
The paper investigates comparative advantages and competitiveness of Hungarian and Slovenian agro- food trade in the EU markets. Applying a highly disaggregated trade dataset, we describe the pattern of agro- food trade in Hungary and Slovenia using the ...
Bojnec, Stefan, Ferto, Imre
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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