Results 71 to 80 of about 143,403 (332)

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

open access: yesAdvanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho   +12 more
wiley   +1 more source

Food hypersensitivity and allergic diseases [PDF]

open access: yesEuropean Journal of Clinical Nutrition, 2002
Allergic disease is a common cause of morbidity, particularly in young children. The prevalence of allergic disease has increased in the last 20 y in most countries. The sequential order of occurrence of allergy is food hypersensitivity, gastrointestinal manifestations, atopic eczema, asthma and hay fever.
openaire   +3 more sources

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

open access: yesAdvanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu   +14 more
wiley   +1 more source

Did food allergy develop in the process of animal evolution?

open access: yesElectronic Physician, 2016
Food allergy is pathophysiologic ally based on stimulation of the immune system at the first exposure, and allergic reactions develop during following exposures. Therefore, memory is the cornerstone of an allergy, as seen in the adaptive immune system.
Seyed Hesamedin Nabavizadeh   +2 more
doaj   +1 more source

OsNRT1.1B‐OsCNGC14/16‐Ca2+‐OsNLP3 Pathway: Phosphorylation‐Mediated Maintenance of Nitrogen Homeostasis

open access: yesAdvanced Science, EarlyView.
OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang   +9 more
wiley   +1 more source

Use of Propolis chemical and Asian tiger mosquito bites : case report and review [PDF]

open access: yes, 2013
Propolis is a substance of variable composition which incorporates resins derived from plants and beeswax. It varies depending on the geographic location and local flora such as plant and bee species.
Muscat, Michelle
core  

Multi‐Dimensional Synergistic Engineering for Boosting Nanozyme Catalysis

open access: yesAdvanced Science, EarlyView.
This review systematically analyzes cutting‐edge strategies for boosting nanozyme catalysis through multi‐dimensional synergistic engineering, containing morphology, electronic structure modulation, external stimulation, and machine learning‐aided design.
Yuechun Li   +6 more
wiley   +1 more source

Engineered Nanomaterials and Type I Allergic Hypersensitivity Reactions

open access: yesFrontiers in Immunology, 2020
Type I allergic hypersensitivity disorders (atopy) including asthma, atopic dermatitis, allergic rhinitis, and food allergy are on the rise in developed and developing countries.
Nasser B. Alsaleh, Jared M. Brown
doaj   +1 more source

Sensitization profiles to purified plant food allergens among pediatric patients with allergy to banana. [PDF]

open access: yes, 2011
Banana fruit allergy is well known, but neither immunoglobulin E recognition patterns to purified plant food allergens nor true prevalences of putative banana allergens have been established. This study aimed to characterize β-1,3-glucanase and thaumatin-
Bobolea, Irina   +7 more
core   +2 more sources

Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury

open access: yesAdvanced Science, EarlyView.
A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi   +11 more
wiley   +1 more source

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