Results 91 to 100 of about 2,093,003 (309)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Definition and Identification of Honey Bee Welfare Practices Within the Five Domains Framework for Sustainable Beekeeping

open access: yesApplied Sciences
This paper aims to define and identify the Honey Bee Welfare Practices (HBWPs) that beekeepers should adopt within a modern framework for sustainable apiculture.
Giovanni Formato   +7 more
doaj   +1 more source

Food safety knowledge, attitudes and practices of institutional food-handlers in Ghana

open access: yesBMC Public Health, 2017
Background In large scale cooking, food is handled by many individuals, thereby increasing the chances of food contamination due to improper handling. Deliberate or accidental contamination of food during large scale production might endanger the health ...
Fortune Akabanda   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Categorisation of the One Welfare Practices in Beekeeping

open access: yesAnimals
Honey bees are vital to ecosystem conservation, agricultural production, and biodiversity, yet their welfare has often been overlooked. This study introduces the integration of Honey Bee Welfare Practices (HBWPs) into the One Welfare framework ...
Claudia Mortellaro   +9 more
doaj   +1 more source

Transitions alimentaires en rural : pratiques et représentations habitantes

open access: yesBulletin de l’Association de Géographes Français, 2019
While transition to sustainable food appears as an urban phenomenon, this article focuses on the practices and representations of the inhabitants of peri-urban and rural areas as eaters, residents and citizens.
Perrine Vandenbroucke, Claire Delfosse
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Fearless: Anastasia Maisel

open access: yes, 2014
Working to create a meaningful, respectful, and community-minded Day of Service in honor of Gettysburg College student Emily Silverstein ’11, and continually involved in different farming and food initiatives in the Gettysburg area to promote food ...
Maisel, Anastasia M.
core  

Combining nested markets and the multilevel perspective to understand the agroecological transition of the food system [PDF]

open access: yes, 2018
A twofold framework based on nested markets and the multi-level perspective on sustainable transitions is presented. We argue that there are promising intersections between these interrelated concepts, which are useful to understand the emerging dynamics
Cerdan, Claire   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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