Results 71 to 80 of about 2,093,003 (309)
A Land Not Forgotten: Indigenous Food Security & Land-Based Practices in Northern Ontario by Michael A. Robidoux and Courtney W. Mason [PDF]
, 2018 Review of Michael A. Robidoux and Courtney W.
Payne, Tonia L, Ph.D.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Geografares, 2018 The article begins with a discussion of the field of studies of Subjectivity (GUATTARI, ROLNIK, 2010), to reflect on subjective modes of production, through eating practices in the context of the contemporary city.
Camila Caires Craveiro
doaj +1 more source
How to integrate sustainable consumption and healthy eating in curriculum - An in-depth probing of the concept of whole school approach [PDF]
, 2009 This study inquired into integration of sustainable consumption and healthy eating in curriculum of three Finnish primary case schools, and carried out a preliminary in-depth probing into the working and outcomes of the 'whole school approach' in terms ...
Mikkola, Minna
core
Enhancing Food Security in a Changing Climate in Africa [PDF]
, 2020 Climate and socio-ecological change scenarios are invaluable tools in developing appropriate response options for ensuring food security and human wellbeing in the future: evidence-based approach.
Africa Group of Negotiators Expert Support
core +1 more source
Determinants of Food Safety Practices Among Food Handlers in Selected Food Establishments [PDF]
, 2019 Despite great efforts against foodborne diseases, the occurrence of these problems remains a significant health issue in both developed and developing countries.
Oumer, A. (Abdu)
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source