Results 91 to 100 of about 866,519 (264)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effect of Mulberry Powder Addition on the Quality and Antioxidant Capacity of Steamed Bread

Liang you shipin ke-ji
This study investigated the effects of replacing flour with different proportions of mulberry fruit powder on the quality and antioxidant properties of steamed bread, with the goal of preparing steamed bread with high nutritional value and expanding the ...
WANG Jing-han, DU Mi-ying, HUANG Shui-lian, DAI Rui   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Optimization of Ultra-High-Pressure Extraction and Comparative Evaluation of Antioxidant Activity and Flavonoid Composition in Guanxiang Leaves

Separations
This paper aimed to optimize the ultra-high-pressure extraction process of flavonoids from guanxiang leaves, evaluate their antioxidant capacity, and identify the flavonoids. Methods: Guanxiang leaves were used as the raw material. The extraction process
Jinyan Zhang, Jiyao Kang, Haoqian Yan, Yang Zhang, Zhenhu Guo, Lihui Liu, Guifeng Zhang, Yu Zhang   +7 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy

Frontiers in Immunology
IntroductionOsteoporosis remains a major global health challenge, and current single-pathway therapies often fail to achieve coordinated bone remodeling. Dickkopf-1 (DKK-1) is a potent inhibitor of the Wnt/β-catenin signaling pathway and plays a critical
Sheng Hou, Sheng Hou, Sheng Hou, Sheng Hou, Tianyu Gao, Tianyu Gao, Tianyu Gao, Yimei Wu, Yimei Wu, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Jin Xu, Jin Xu, Jin Xu, Huaizu Guo, Huaizu Guo, Huaizu Guo, Weizhu Qian, Weizhu Qian, Weizhu Qian, Weizhu Qian   +30 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Macrophage-targeted liposomes as a nano-immunomodulator for rheumatoid arthritis: Harnessing the therapeutic potential of white asparagus polysaccharides

Food Hydrocolloids for Health
Therapeutic delivery to inflamed joints remains a critical challenge in rheumatoid arthritis (RA) management due to systemic clearance and nonspecific biodistribution. Within the RA synovial microenvironment, macrophage activation as a central pathogenic
Munire Abudurexiti, Li Chen, Shuangjiang Cheng, Rongrui Zhang, E. Zhang, Yafei Ma, Lu Han, Lili He, Qiang Liu, Zhi-xiang Yuan   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Predation dynamics of Rhodeus sinensis on Procambarus clarkii larvae: Behavioral patterns and aquatic plant refuge effects in crayfish aquaculture

Aquaculture Reports
Non-target fish are frequently present in crayfish aquaculture systems, yet limited research has explored their predatory impacts on crayfish larvae.
Shiyu Jin, Dangen Gu, Tanglin Zhang, Zhiqiang Xu, Yu Xu, Meng Wang, Qishuo Wang, Yan Luo, Zhen Qian, Zhengyi Zhu, Mengmei Zou, Si Luo   +11 more
doaj   +1 more source