Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression
The FEBS Journal, EarlyView.T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera +5 more
wiley +1 more source
The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells [PDF]
, 2007 Nicolas Jonckheere +10 more
openalex +1 more source
Journal of Fish Biology, EarlyView.Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne +4 more
wiley +1 more source
Journal of Periodontal Research, EarlyView.NF‐κB/FOXO3a/c‐JUN pathway plays a crucial role in osteogenic. Differentiation of aged PDLCs in an inflammatory microenvironment, although the mechanisms of this pathway differ in cellular ageing and pathological inflammation. ABSTRACT Aim This study aims to investigate the effect of inflammation on the senescence phenotype and osteogenic capacity of ...
Luying Zhu +6 more
wiley +1 more source
The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation
, 2004 Kathryn E. Davis +2 more
openalex +1 more source
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
The AKT Forkhead box O transcription factor axis regulates human cytomegalovirus replication [PDF]
, 2022 Hongbo Zhang +4 more
openalex +1 more source
USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies
Annals of the New York Academy of Sciences, EarlyView.USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge +5 more
wiley +1 more source
Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation [PDF]
, 2011 Mónica Álvarez‐Fernández +4 more
openalex +3 more sources