Results 191 to 200 of about 56,919 (302)

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells

open access: yesThe FEBS Journal, EarlyView.
TSC22D1 acts downstream of glucose signaling and negatively regulates insulin secretion in pancreatic beta cells. Mechanistically, TSC22D1 interacts with FoxO1. Elevated glucose levels enhance the TSC22D1–FoxO1 interaction indirectly by increasing the protein abundance of TSC22D1. Importantly, TSC22D1 and FoxO1 not only physically associate but also co‐
Sümbül Yıldırım   +11 more
wiley   +1 more source

Mechanistic insights into dental stem cells‐derived exosomes in regenerative endodontics

open access: yesInternational Endodontic Journal, EarlyView.
Abstract Background Dental pulp is a richly vascularised and innervated tissue vital for tooth vitality, sensory function, and structural integrity. While conventional root canal therapy effectively treats necrotic permanent teeth, it irreversibly eliminates pulp vitality, potentially increasing the risk of secondary infections and long‐term structural
Paras Ahmad   +4 more
wiley   +1 more source

Regulatory T Cell Dysregulation in Vitiligo: A Meta‐Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives

open access: yesInternational Journal of Dermatology, EarlyView.
Schematic representation of the methodology, key findings and implications in the context of immune mechanisms and treatment perspectives for vitiligo from the meta‐analysis and systematic review. ABSTRACT Vitiligo is an autoimmune disorder marked by the progressive loss of skin melanocytes, increasingly linked to immune dysregulation as a key driver ...
Gabriela Lerner   +9 more
wiley   +1 more source

Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8+ Cells and TNF‐α Levels in Target Organs, and Protects Mice From Graft‐Versus‐Host Disease‐Related Mortality Through PPAR Activation Without Compromising the Graft‐Versus‐Tumour Response

open access: yesImmunology, EarlyView.
Effect of Palmitoylethanolamide (PEA) in a murine model of graft‐versus‐host disease (GVHD). Following an allogeneic transplant from C57BL/6J donors to BALB/c recipients, PEA treatment improved survival, alleviated clinical symptoms, and protected target organs in GVHD‐affected mice.
Bárbara Betônico Berg   +9 more
wiley   +1 more source

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