Results 211 to 220 of about 63,239 (293)

From Multiple Congenital Anomalies to Pituitary Gland Malformation: Wide Spectrum of Clinical Features in a Family With FOXA2 Variant

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1452-1457, June 2026.
ABSTRACT FOXA2 (hepatocyte nuclear factor‐3β, HNF‐3β) encodes a transcriptional activator involved in early embryogenesis, particularly in the patterning and differentiation of midline structures such as the neural tube, foregut, and pituitary gland. Its role in human pathogenesis was first suspected when patients with deletion of chromosome 20p11.2 ...
Christopher Connolly   +3 more
wiley   +1 more source

Foxp3+/CD4+ Cell Ratio in Primary Colorectal Cancer Predicts Opposite Prognoses Following Resection of Synchronous or Metachronous Liver Metastases

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
The study evaluated the abundance, distribution, and prognostic significance of Foxp3+ and CD4+ T cells, as well as their ratio, in tumor center (TC), inner invasive margine (IM), outer invasive margine (OM) and peritumor zone (PT) of primary colorectal cancer (pCRC) and liver metastases (LM) in patients with synchronous and metachronous disease ...
Andriy Trailin   +10 more
wiley   +1 more source

Harnessing Gut Microbiota to Enhance Immunotherapy in NSCLC: From Mechanisms to Translational Applications

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT The gut microbiome has emerged as a pivotal regulator of immunotherapy efficacy in non‐small cell lung cancer (NSCLC), with mounting evidence demonstrating that microbial‐immune crosstalk significantly influences therapeutic responses. Current research reveals that commensal bacteria modulate host immunity through complex metabolic and ...
Liming Zhu   +4 more
wiley   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun   +7 more
wiley   +1 more source

Landscape of Immune Remodeling and NAP1L1‐Driven Epithelial Reprogramming in Gastric Cancer Metastasis

open access: yesChronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 126-138, June 2026.
High‐resolution single‐cell atlas of normal gastric tissue, primary gastric cancer, and metastatic lesions. (A) Schematic diagram of experimental design. (B) Bar plot for qualified cell numbers in each lesion. (C) Cells annotation by canon markers for all cells. (D) Bubble chart for canon marker genes for each cell subtype.
Min Sun   +3 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

open access: yeseFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie   +5 more
wiley   +1 more source

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions

open access: yesEuropean Journal of Immunology, Volume 56, Issue 6, June 2026.
Using cyclic multiplex microscopy in an IL‐33‐driven type 2 inflammation model, we validated a spatial workflow mapping rare lung ILCs. High‐dimensional analysis revealed a conserved peri‐lymphatic niche at early time points of inflammation where ILC2s and myeloid cells co‐localize with LYVE1+ vessels, highlighting a structured immunological ...
Sandy Kroh   +10 more
wiley   +1 more source

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