Results 221 to 230 of about 94,249 (285)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

The FOXA transcription factors in allergic airway disease and asthma. [PDF]

Front Allergy
Yánez DC, Lau CI, Rowell J, Zhang E, Crompton T.   +4 more
europepmc   +1 more source

Single‐Cell Analysis Identified a Recurrent Malignant‐Associated Transcriptional State in Colorectal Cancer

Cancer Science, Volume 117, Issue 5, Page 1397-1411, May 2026.
Colorectal cancer (CRC) shows high molecular heterogeneity, yet single‐cell data from Japanese patients are limited. We performed scRNA‐seq on tumors and adjacent normal tissues from four Japanese CRC patients and identified a shared malignant cell cluster with high KCNQ1OT1 expression and reduced RASSF6 levels.
Sadahiro Iwabuchi, Kentaro Sawada, Motohiro Kojima, Miho Ozawa, Hiroya Taniguchi, Hideaki Bando, Kazumi Abe, Yuta Kuze, Kiyomi Imamura, Yukie Kashima, Yoshihiko Hirohashi, Atsushi Tajima, Toshihiko Torigoe, Yutaka Suzuki, Takayuki Yoshino, Shinichi Hashimoto   +15 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo, Marina Mejias‐Ortega, Verónica López‐López, Aysha M. Bhojwani‐Cabrera, Emma Saxton, Santiago Canals, Giles Hardingham, Antonia Gutierrez, Jose P. Lopez‐Atalaya, Silvia De Santis   +9 more
wiley   +1 more source

Butyrate Silences <i>MUC5AC</i> in Airway Epithelial Cells Through Histone Deacetylation at Its Promoter Region. [PDF]

Allergy Asthma Immunol Res
Jo SH, Bae I, Sim MS, Kim HJ, Kim C, Chung IY, Chang HS.   +6 more
europepmc   +1 more source

Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway. [PDF]

Dev Cell, 2012
Ahmad SM, Tansey TR, Busser BW, Nolte MT, Jeffries N, Gisselbrecht SS, Rusan NM, Michelson AM.   +7 more
europepmc   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Foxj2 Attenuates LPS-Induced Inflammatory Response in Macrophages. [PDF]

Mediators Inflamm
Huang P, Fu J, Hu J, Lei Y, Dai C, Wu T, Liu J.   +6 more
europepmc   +1 more source

A high-content screen identifies inhibitors of nuclear export of forkhead transcription factors. [PDF]

J Biomol Screen, 2011
Bouck DC, Shu P, Cui J, Shelat A, Chen T.   +4 more
europepmc   +1 more source