Results 221 to 230 of about 7,923,952 (292)
Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways. [PDF]
Aging AdvMaiese K.
europepmc +1 more source
ApoE4 as a Therapeutic Target in Epilepsy: From Pathogenic Mechanisms to Precision Medicine
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.ApoE4 acts as a key disease modifier in epilepsy by driving neuroinflammation, synaptic dysfunction, metabolic imbalance, and BBB disruption. These interacted mechanisms promote network hyperexcitability and disease progression. Targeting ApoE4 and its downstream pathways offers promising opportunities for precision therapy.
Kang Pan +4 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.The high expression of PRMT7 enhances its interaction with DVL2 by methylating arginine residues on FOXK1/FOXK2. This process promotes the nuclear translocation of DVL2, thereby aberrantly activating the Wnt/β‐catenin signalling pathway, which ultimately drives the development of doxorubicin resistance in DLBCL.
Xiaoyan Zhao +7 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Neoadjuvant‐treated PDAC tumors were stratified into responders and non‐responders based on CAP guidelines snRNA‐seq, snATAC‐seq, and spatial transcriptomics can be used to profile the neoadjuvant‐chemotherapy‐treated PDAC immune landscape. Our exploratory findings nominate candidate myeloid features for validation in larger cohorts and functional ...
Mercy Ojetunde +11 more
wiley +1 more source
FOXK1: a multifaceted regulator in metabolic reprogramming and disease progression. [PDF]
Biol DirectHe T, Ma G, Yuan G.
europepmc +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang +5 more
wiley +1 more source
Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Graphical Highlights Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer. Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches. Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.
Xinfeng Yang +9 more
wiley +1 more source
Transcriptomic Mechanisms Underlying Dietary Fish Oil, Phospholipid, and Vitamin E Supplementation in Promoting Ovarian Development in <i>Leptobotia elongata</i>. [PDF]
Animals (Basel)Jiang Y +6 more
europepmc +1 more source
Food Biomacromolecules, Volume 3, Issue 3, Page 444-465, September 2026.Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
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Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, Volume 3, Issue 3, September 2026.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source