Results 221 to 230 of about 63,239 (293)

Roles of histone lysine methylation in neurodevelopment and related disorders

Ibrain, Volume 12, Issue 2, Page 201-221, Summer 2026.
This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen, Yi Zhang, Hong Zhang, Xiaoli Liang   +3 more
wiley   +1 more source

A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription. [PDF]

Cell Rep
Kim J, Xie S, Valenzuela LF, Xiao J, Lanz MC, Gao X, Swaffer M, Mitchell CE, Rubin SM, Schmoller K, Skotheim JM.   +10 more
europepmc   +1 more source

Propolis Flavonoids Ameliorate Chronic Osteomyelitis in a Rat Model by Modulating TAZ‐Regulated Treg/Th17 Balance

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
This diagram illustrates the mechanism by which Propolis Flavonoids (PF) ameliorate Chronic Osteomyelitis (COM). PF upregulates the transcriptional coactivator TAZ, which is suppressed in COM. Elevated TAZ restores Treg/Th17 homeostasis by promoting the Th17‐master regulator RORγt while suppressing the Treg‐specific transcription factor FOXP3.
Yujie Wang, Chaozhu Zhang, Zeyang He, Liqiang Li   +3 more
wiley   +1 more source

Overexpression of FOXO1 may suppress proliferation and migration and correlate with tumor immune cells in nasopharyngeal carcinoma. [PDF]

Transl Cancer Res
Yu P, Wei W, Wu G, Liu X, Qin S, Ma H, Feng L, Cai Y, Liu L.   +8 more
europepmc   +1 more source

Current Progress in Differentiating Crohn's Disease From Intestinal Tuberculosis

iLABMED, Volume 4, Issue 2, Page 78-90, June 2026.
Currently, there are various methods from different fields used to differentiate Crohn's disease from intestinal tuberculosis (ITB). Endoscopic findings are an important cornerstone. They can be used individually or in combination (models) to demonstrate excellent discriminative ability.
Chuyao Zhang, Xiaoyin Zhang
wiley   +1 more source

Two Forkhead transcription factors regulate cardiac progenitor specification by controlling the expression of receptors of the fibroblast growth factor and Wnt signaling pathways.

Development, 2016
Ahmad SM, Bhattacharyya P, Jeffries N, Gisselbrecht SS, Michelson AM.   +4 more
europepmc   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Intragenic loss-of-function variants in transcription factors <i>MAZ</i>, <i>FOXP1</i> and <i>SIN3B</i> in colobomatous microphthalmia. [PDF]

J Med Genet
Seese SE, Reis LM, Schneider A, Bardakjian T, Semina EV.   +4 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis. [PDF]

Gut
Sasaki M, Wang JX, Teranishi R, Itami T, Zhou Y, Kennedy KV, Semeao A, Ishikawa S, Hara T, McMillan EA, Mahon M, Golden H, Dhakal D, Baccarella A, Winters H, Umeweni CN, Wilkins BJ, Karakasheva TA, Whelan KA, Shaffer SM, Ruffner MA, Muir AB.   +21 more
europepmc   +1 more source