Results 231 to 240 of about 63,239 (293)

Controversies Surrounding Critical‐Size Defects: Influence of Age and Biological Characteristics

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 6, June 2026.
ABSTRACT Critical‐size defects (CSDs) in craniofacial reconstruction refer to osseous gaps that fail to heal spontaneously, increasing the risk of neurological impairment and craniofacial dysmorphology. Despite decades of investigation, controversy still exists surrounding the definition of CSDs, with criteria varying across species, experimental ...
Andrew Nordlund, Hana Shah, Nicholas A. Mirsky, Kashyap K. Tadisina, Arturo J. Rios‐Diaz, Vasudev Vivekanand Nayak, Estevam A. Bonfante, Paulo G. Coelho   +7 more
wiley   +1 more source

Ancient regulatory evolution shapes individual language abilities in present-day humans. [PDF]

Sci Adv
Casten LG, Koomar T, Thomas TR, Koh JY, Hofammann D, Thenuwara S, Momany A, O'Brien M, Murray JC, Tomblin JB, Michaelson JJ.   +10 more
europepmc   +1 more source

Integrated Molecular Docking and Gene Expression Analyses Suggest a Potential Interaction Between Diphtheria Toxin and Bcl‐2 in HT‐29 Colorectal Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This study explores the interaction between Diphtheria Toxin (DT) and Bcl‐2 in HT‐29 cells. Integrating molecular docking with gene expression analysis, we demonstrate DT's high‐affinity binding to Bcl‐2 and a significant downregulation of BCL2 mRNA. These findings suggest that DT modulates anti‐apoptotic pathways, influencing colorectal cancer cell ...
Elif Ercan, Tugba Yalcinkaya, Belkis Levent, Ahmet Carhan   +3 more
wiley   +1 more source

Ubiquitin-specific protease 5 promotes breast cancer progression by stabilizing Forkhead box M1 through deubiquitination. [PDF]

Cytojournal
Wang X, Chen T, Wu S, Wu Y.
europepmc   +1 more source

USP54 Promotes Ferroptosis in Non‐Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei, Yong‐Ping Liu, Chun‐Dong Gu, Shi‐Lei Zhao, Li Feng, Jian‐Rong Yu   +5 more
wiley   +1 more source

From Tregs to tissue remodelling: FOXP3 and IL-35 in the inflammatory landscape of nasal polyps. [PDF]

Inflamm Res
Gokulakannan G, Che Jalil NA, Kadir R, Ramli RR, Abdullah B, Lambuk F, Md Shukri N.   +6 more
europepmc   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

The FOXA transcription factors in allergic airway disease and asthma. [PDF]

Front Allergy
Yánez DC, Lau CI, Rowell J, Zhang E, Crompton T.   +4 more
europepmc   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Multidimensional Regulatory Network and Spatiotemporal Specificity of FOXO Transcription Factors in Digestive System Tumors: Recent Advances. [PDF]

Int J Mol Sci
Cheng S, Zhang S, Quan J, Jin M.
europepmc   +1 more source