Results 41 to 50 of about 8,070,408 (246)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Four Dimensional Model of Formal and Informal Learning

, 2008
Learning systems focused on collaborative learning are often described in terms of formal and informal learning, however definitions of formal and informal learning vary, which makes it difficult to compare systems that may have been described using ...
Chen, Wen-Pin, Millard, David, Wills, Gary   +2 more
core   +1 more source

Teachers as brokers: Bridging formal and informal learning in the 21st century

KEDI Journal of Educational Policy, 2012
A review of schooling practices from learners’ and teachers’ perspectives relative to 21st century goals is conducted. Although schools try to embed 21st century literacies into the curriculum, there is an overemphasis on content knowledge.
David Hung, Shu-Shing Lee, Kenneth Y. T. Lim   +2 more
doaj   +1 more source

A Framework for Mobile Learning Acceptance Amongst Formal Part-Time Learners: From the Andragogy Perspective

IEEE Access, 2022
Mobile learning is posited to be an effective learning tool for various learners. However, limited studies have been conducted to explore formal part-time learners’ behavior towards mobile learning.
Shima Sabri, Abdullah Gani, Elaheh Yadegaridehkordi, Shuhadah Othman, Faizah Miserom, Liyana Shuib   +5 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Workplace Learning: Main Themes & Perspectives [PDF]

This paper provides an overview and critical discussion of some of the main themes and perspectives within existing academic literature concerning workplace learning.
Lee, Tracey, Felstead, Alan, Fuller,, Alison, Ashton, David, Unwin, Lorna, Walters, Sally, Butler, Peter   +6 more
core   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Integrating Formal and Non-Formal Learning: A Qualitative and Quantitative Study of Innovative Teaching Strategies in Secondary Schools

Education Sciences
This study explores the impact of integrating formal and non-formal learning in secondary school education through a mixed-methods experimental design.
Gianluca Gravino, Davide Di Palma, Fabiola Palmiero, Generoso Romano, Maria Giovanna Tafuri   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source