Mechanism of Antinociceptive Effect of Vanillin in Formalin Test [PDF]
International Journal of Preventive MedicineBackgrounds: Vanillin is the active component of Vanillus planifolia seeds and is widely used as a flavoring agent in food and pharmaceutical industries. It has shown anti-inflammatory and antinociceptive properties.
Valiollah Hajhashemi +2 more
doaj +5 more sources
Differential Antinociceptive Efficacy of Peel Extracts and Lyophilized Juices of Three Varieties of Mexican Pomegranate (Punica granatum L.) in the Formalin Test [PDF]
Plants, 2022 Pharmacological treatment of pain often causes undesirable effects, so it is necessary to look for natural, safe, and effective alternatives to alleviate painful behavior.
José Antonio Guerrero-Solano +8 more
doaj +2 more sources
Involvement of Endogenous Opioid System in Swim Stress-Induced Pain Modulation During the Interphase of the Formalin Test [PDF]
Basic and Clinical Neuroscience, 2019 Introduction: Some evidence demonstrates endogenous inhibitory pathways of pain involved in the interphase (phase between early and later phase) of the formalin test.
Ali Reza Moslem +3 more
doaj +2 more sources
EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST [PDF]
Acta Medica Iranica, 1999 In this study, the effects of acute and chronic lithium on nociception induced by formalin and its interactions with morphine-induced analgesia were studied in mice. Formalin test was selected to study nociception.
M. Sharifzadeh +5 more
doaj +2 more sources
Modulation of Different Phases of Formalin Test by Force Swim Stress [PDF]
Basic and Clinical Neuroscience, 2014 Introduction: The formalin test is the most accepted chemical test for evaluation of nociception. It requires the injection of an adequate amount of formalin into the surface of the hindpaw. Formalin test consists of phase 1 (0-7 min) and phase 2 (15-60)
Mohammad Mohammad-Zadeh +3 more
doaj +1 more source
Rapid development of tolerance to morphine in the formalin test
NeuroReport, 1994 Previous reports have suggested that tolerance to the antinociceptive effects of morphine does not develop in the formalin test. To re-examine these findings, morphine was administered via multiple injections or continuous infusion from 0 to 4 days prior to testing with either the formalin or tail-flick test. Following twice daily injections (5.0 mg kg-
B J, Connell +3 more
openaire +3 more sources
A refinement to the formalin test in mice. [PDF]
F1000Res, 2019 The constant refinement of tests used in animal research is crucial for the scientific community. This is particularly true for the field of pain research, where ethical standards are notably sensitive. The formalin test is widely used in pain research and some of its mechanisms resemble those underlying clinical pain in humans.
Lopes DM +4 more
europepmc +6 more sources
Permanent lesion in rostral ventromedial medulla potentiates swim stress-induced analgesia in formalin test [PDF]
Iranian Journal of Basic Medical Sciences, 2014 Objective(s): There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced ...
Ali Shamsizadeh +3 more
doaj +1 more source
Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice
Frontiers in Medicine, 2021 Chronic itch is a common distressing symptom of many diseases, which reduced patient's quality of life. The mechanistic study on itch and screening for new anti-itch drugs require the development of new pre-clinical itch animal models.
Xu Liu +10 more
doaj +1 more source
PEMBERDAYAAN MASYARAKAT DALAM MINIMALISASI RISIKO PAPARAN FORMALIN PADA BAHAN MAKANAN
LINK, 2023 Formalin merupakan bahan kimia yang digunakan sebagai pengawet dalam bahan makanan. Bahan ini bersifat karsinogenik, akumulasi yang tinggi dalam tubuh akan menyebabkan iritasi lambung, alergi sampai terjadinya kanker saluran cerna.
Angki Purwanti +2 more
doaj +1 more source