Results 41 to 50 of about 397,381 (260)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
L’enseignement technologique et professionnel français... et la formation tout au long de la vie
Revue Internationale d’Éducation de Sèvres, 1997 Étudiant les évolutions de la formation initiale et professionnelle d’une catégorie de la population, celle des ouvriers et employés, l’auteur démontre, preuves à l’appui, qu’il y a nécessité à reformuler les objectifs de la formation initiale et à ...
Benoît Bouyx
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Médiations & Médiatisations, 2020 Les dispositifs technopédagogiques de type visioconférence sont des technologies émergentes de plus en plus utilisées en enseignement supérieur. Certains établissements d’enseignement investissent largement dans leur implantation et dans leur déploiement
Simon Bolduc +4 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Démarche partagée d'individualisation en formation initiale et continue
Revue Internationale d’Éducation de Sèvres, 1997 Les démarches d'individualisation sont un autre exemple de dispositif partagé : les formations générales et professionnelles, quelles soient initiales, différées, continues, tendent à échanger et adapter leurs procédures.
Michel Hauw, Guy Marchant
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Importance et difficulté de prendre en compte la mesure dans un système qualité universitaire
The Journal of Quality in Education, 2019 La maîtrise de la qualité de tout système passe par la maîtrise d'un processus de production de valeur, mais également - et on l'oublie trop souvent - par la maîtrise des processus de mesure.
MAURICE PILLET +2 more
doaj +1 more source