Results 131 to 140 of about 344,749 (312)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Late Archaic-Early Formative period microbotanical evidence for potato at Jiskairumoko in the Titicaca Basin of southern Peru. [PDF]
Proc Natl Acad Sci U S A, 2016 Rumold CU, Aldenderfer MS.
europepmc +1 more source
Pahiatua borough : the formative years (1881-1892) : a thesis presented in partial fufilment of the requirements for the degree of Master of Arts in History at Massey University [PDF]
, 1973 To the New Zealand citizen of the 1970's, surrounded either by the tall buildings of an urban landscape, or the predominantly open fields of a rural environment, the terms Seventy and Forty mile bush may connote more of a legendary forest tract, than the
Bentley, Byron John
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Normal forms for periodic systems
Journal of Mathematical Analysis and Applications, 1986 The author develops the theory of normal forms for t-periodic vector fields, fleshing out a brief description of the theory in the book by \textit{V. I. Arnold}, Geometrical methods in the theory of ordinary differential equations (1983; Zbl 0507.34003).
openaire +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Estudios Atacameños, 2012 El proceso de cambio de una sociedad de pescadores- recolectores,como los grupos Chinchorro, hacia una sociedad agrícola más sedentaria, como se ha planteado para las poblaciones Faldas del Morro y Alto Ramírez, no solo implicó un cambio en la ...
Iván Ricardo Muñoz Ovalle +1 more
doaj