Results 121 to 130 of about 11,686 (159)
Intratracheal transplantation of mesenchymal stem cells attenuates hyperoxia-induced lung injury by down-regulating, but not direct inhibiting formyl peptide receptor 1 in the newborn mice. [PDF]
PLoS One, 2018 Kim YE +4 more
europepmc +1 more source
Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. [PDF]
Biochem Pharmacol, 2014 Schepetkin IA +5 more
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The potential impacts of formyl peptide receptor 1 in inflammatory diseases
Frontiers in Bioscience - Elite, 2016 Neutrophils play a critical role in acute and chronic inflammatory diseases. N-formyl peptides, which originate from bacterial peptides or mitochondrial proteins bind with a high binding affinity to formyl peptide receptor 1 (FPR1). N-formyl peptide-FPR1 is involved in the pathogenesis of sterile and infectious inflammatory processes and causes ...
Shun-Chin Yang, Tsong-Long Hwang
exaly +5 more sources
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N-Formylated humanin activates both formyl peptide receptor-like 1 and 2
Biochemical and Biophysical Research Communications, 2004We have discovered that humanin (HN) acts as a ligand for formyl peptide receptor-like 1 (FPRL1) and 2 (FPRL2). This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). In addition, we found that N-formylated HN (fHN)
Shuji Hinuma +2 more
exaly +3 more sources
Biochemical Pharmacology, 2007
The anti-inflammatory drug piroxicam has been reported to affect the production of reactive oxygen species in phagocytes. This anti-inflammatory effect is thought to be mediated through inhibition of cyclooxygenase (COX), an enzyme important for prostaglandin synthesis.
Christine Wennerås, Claes Dahlgren
exaly +3 more sources
The anti-inflammatory drug piroxicam has been reported to affect the production of reactive oxygen species in phagocytes. This anti-inflammatory effect is thought to be mediated through inhibition of cyclooxygenase (COX), an enzyme important for prostaglandin synthesis.
Christine Wennerås, Claes Dahlgren
exaly +3 more sources
A Novel Nonpeptide Ligand for Formyl Peptide Receptor-Like 1
Molecular Pharmacology, 2004Formyl peptide receptor-like 1 (FPRL1) is a G protein-coupled receptor that binds natural and synthetic peptides as well as lipoxin A(4) and mediates important biological functions. To facilitate its pharmacological characterization, we screened a compound library and identified a substituted quinazolinone (Quin-C1, 4-butoxy-N-[2-(4-methoxy-phenyl)-4 ...
Masakatsu, Nanamori +7 more
openaire +2 more sources
Formyl peptide receptor 1 signaling potentiates inflammatory brain injury
Science Translational Medicine, 2021Formyl peptide receptor 1 facilitates brain inflammation and can be targeted to attenuate acute neural injury.
Zhiguo Li +7 more
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Signal Transduction of Hyaluronic Acid−Peptide Conjugate for Formyl Peptide Receptor Like 1 Receptor
Bioconjugate Chemistry, 2008Agonistic and antagonistic peptides for formyl peptide receptor like 1 (FPRL1) receptor have been investigated as novel drug candidates for inflammatory diseases such as sepsis, asthma, and rheumatoid arthritis. In this work, a novel protocol for the synthesis of hyaluronic acid (HA)-peptide (CWRYMVm) conjugate for FPRL1 receptor was successfully ...
Oh, EJ +4 more
openaire +3 more sources
Biochemical Pharmacology, 2012
The neutrophil formyl peptide receptors (FPR1 and FPR2) are members of the G-protein coupled receptor family. The signals generated by occupied FPRs are both pro-inflammatory and anti-inflammatory. Accordingly, these receptors have become a therapeutic target for the development of novel drugs that may be used to reduce injuries in inflammatory ...
Çevik-Aras H +5 more
openaire +3 more sources
The neutrophil formyl peptide receptors (FPR1 and FPR2) are members of the G-protein coupled receptor family. The signals generated by occupied FPRs are both pro-inflammatory and anti-inflammatory. Accordingly, these receptors have become a therapeutic target for the development of novel drugs that may be used to reduce injuries in inflammatory ...
Çevik-Aras H +5 more
openaire +3 more sources
European Journal of Medicinal Chemistry, 2018
The receptor for the urokinase-type plasminogen activator (uPAR) is a widely recognized master regulator of cell migration. We and others have previously documented that the uPAR(84-95) sequence, interacts with the formyl peptide receptors (FPR)s, henceforth inducing cell migration of several cell lines, including leukocytes, and the synthetic shorter ...
Yousif, Ali Munaim +9 more
openaire +3 more sources
The receptor for the urokinase-type plasminogen activator (uPAR) is a widely recognized master regulator of cell migration. We and others have previously documented that the uPAR(84-95) sequence, interacts with the formyl peptide receptors (FPR)s, henceforth inducing cell migration of several cell lines, including leukocytes, and the synthetic shorter ...
Yousif, Ali Munaim +9 more
openaire +3 more sources