Results 131 to 140 of about 11,686 (159)

Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration

Science
Multiple sclerosis (MS) progresses through brain region–specific inflammation and degeneration, with poorly defined mechanisms. In individuals with MS, we identified increased expression of formyl peptide receptor 1 (FPR1) in central nervous system (CNS)–resident microglia and CNS-infiltrating macrophages. Blood amounts of
Yulin Li, Zhiguo Li, Pei Zheng, Shuzhen Guan, Yan Li, Nan Yao, Zhihui Qi, Xueyu Zhang, Lei Su, Jing Jing, Siting Wu, Xue Zhao, Meng Wang, Chotima Böttcher, Hans-Gustaf Ljunggren, Friedemann Paul, Luc Van Kaer, Alexei Verkhratsky, Fu-Dong Shi   +18 more
openaire   +3 more sources

Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing

Life Sciences
Formyl peptide receptor 1 (FPR1), from a G-protein coupled receptor family, was previously well-characterized in immune cells. But the function of FPR1 in osteogenesis and fracture healing was rarely reported. This study, using the FPR1 knockout (KO) mouse, is one of the first studies that try to investigate FPR1 function to osteogenic differentiation ...
Xinlin, Yang, Wan'an, Xiao, Quang, Le, Zhichang, Zhang, Weicheng, Wang, Sang-Hyun, Lee, Abhijit, Dighe, Jason R, Kerrigan, Quanjun, Cui   +8 more
openaire   +2 more sources

The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor 1

Biochemical Pharmacology, 2010
The anionic amphiphil sodium dodecyl sulfate (SDS) is commonly used to activate the superoxide-generating NADPH-oxidase complex in cell-free systems, but very little is known about the effects of SDS on intact cells. It was, however, recently shown that SDS causes a translocation and an activation of Rac (a small G-protein) in intact cells, but this ...
Fredrik B, Thorén, Jennie, Karlsson, Claes, Dahlgren, Huamei, Forsman   +3 more
openaire   +2 more sources

Targeting the formyl peptide receptor 1 for treatment of glioblastoma

2023
Background and Aims Gliomas account for over half of all primary brain tumours and have a very poor prognosis, with a median survival of less than two years. There is an urgent and unmet clinical need to develop new therapies against glioma. Recent reports have indicated the overexpression of FPR1 in gliomas particularly in high grade gliomas.
openaire   +1 more source

Formyl Peptide Receptor 1 Promotes Immune Responses to Chemotherapy

Cancer Discovery, 2015
Abstract FPR1 is necessary for efficient T cell–mediated antitumor immune responses to chemotherapy.
openaire   +1 more source

Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury

2016
Neutrophils as key effector cells of the innate immune system migrate from the circulation into sites of inflammation and are essential for the containment, killing and clearance of invading pathogens through a variety of highly regulated cell functions. Despite this beneficial role their involvement can also be detrimental.
openaire   +1 more source

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures

Cells, 2021
Monika Leśkiewicz, Marcello Leopoldo, Wladyslaw Lason   +2 more
exaly  

Development of Small Molecule Non-peptide Formyl Peptide Receptor (FPR) Ligands and Molecular Modeling of Their Recognition

Current Medicinal Chemistry, 2014
Mark Quinn, Andrei Khlebnikov, Agostino Cilibrizzi   +2 more
exaly  

The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology

Current Neuropharmacology, 2020
Monika Leśkiewicz, Marcello Leopoldo, Katarzyna Chamera   +2 more
exaly  

Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor

Biochemical and Biophysical Research Communications, 1992
Eric R Prossnitz, Richard Ye, C G Cochrane   +2 more
exaly