Results 81 to 90 of about 11,686 (159)

No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19

OncoImmunology, 2020
Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells.
Adriana Petrazzuolo, Julie Le Naour, Erika Vacchelli, Pascale Gaussem, Syrine Ellouze, Georges Jourdi, Eric Solary, Michaela Fontenay, David M. Smadja, Guido Kroemer   +9 more
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

The differential expression of adipose tissue genes in short, medium and long-term periods after bariatric surgery

Scientific Reports
Bariatric surgery is an approved treatment for obesity that consistently improves metabolic syndrome, with well-documented beneficial effects on dyslipidemia, cardiovascular risk, nonalcoholic fatty liver disease and glucose homeostasis.
Maryam Mahjoubin-Tehran, Stephen L. Atkin, Tannaz Jamialahmadi, Matthew Kroh, Ali H. Eid, Wael Almahmeed, Amirhossein Sahebkar   +6 more
doaj   +1 more source

Data on the NADPH-oxidase activity induced by WKYMVm and galectin-3 in bone marrow derived and exudated neutrophils isolated from four different mouse strains

Data in Brief, 2017
Neutrophils are the key players in inflammatory reactions and the release of superoxide through the NADPH-oxidase upon neutrophil activation contributes to bacterial clearance and surrounding tissue damage.
Lena Björkman, Huamei Forsman, Karin Önnheim   +2 more
doaj   +1 more source

FPR1: A critical gatekeeper of the heart and brain

Pharmacological Research
G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in the clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1)
Ziyin Zhangsun, Yushu Dong, Jiayou Tang, Zhenxiao Jin, Wangrui Lei, Changyu Wang, Ying Cheng, Baoying Wang, Yang Yang, Huadong Zhao   +9 more
doaj   +1 more source

The G-Protein-Coupled Chemoattractant Receptor Fpr2 Exacerbates High Glucose-Mediated Proinflammatory Responses of Müller Glial Cells

Frontiers in Immunology, 2017
In proliferative diabetic retinopathy (PDR), activated Müller glial cells (MGCs) exhibit increased motility and a fibroblast-like proliferation phenotype that contribute to the formation of fibrovascular membrane.
Ying Yu, Ying Yu, Ying Yu, Zhiyao Bao, Zhiyao Bao, Xiaofei Wang, Xiaofei Wang, Wanghua Gong, Hui Chen, Huaijin Guan, Yingying Le, Shaobo Su, Keqiang Chen, Ji Ming Wang   +13 more
doaj   +1 more source

Agonist-specific FPR1 conformational change prevents receptor recycling and promotes targeted protein degradation

Acta Pharmaceutica Sinica B
Recycling of internalized cell surface receptors is critical for membrane transport and receptor-mediated signaling. Formyl peptide receptor 1 (FPR1) plays important roles in host defense and inflammatory tissue injury.
Junlin Wang, Qiwen Liao, Geng Chen, Yixin Chang, Hong Nie, Jiahong Lu, Richard D. Ye   +6 more
doaj   +1 more source

Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models. [PDF]

Eur J Med Chem, 2023
Francavilla F, Sarcina F, Schepetkin IA, Kirpotina LN, Contino M, Schirizzi A, De Leonardis G, Khlebnikov AI, D'Alessandro R, Quinn MT, Lacivita E, Leopoldo M.   +11 more
europepmc   +1 more source

A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells. [PDF]

RSC Chem Biol, 2023
Field DH, White JS, Warriner SL, Wright MH.   +3 more
europepmc   +1 more source

Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease

Frontiers in Bioscience-Landmark
Therapeutic strategies for ocular diseases are undergoing a transformative shift from symptom management to regenerative and disease-modifying approaches.
Caterina Gagliano, Alessandro Avitabile, Dario Rusciano   +2 more
doaj   +1 more source