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Pleiotropic roles of formyl peptide receptors
Cytokine and Growth Factor Reviews, 2001FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection.
Ji Ming Wang, Yingying Le
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Formyl Peptide Receptor Expression in Birds
Immunopharmacology and Immunotoxicology, 2007N-formyl-methionyl-leucyl-phenylalanine (fMLP) is a major chemotactic factor produced by Escherichia coli and other Gram-negative bacteria. The prototypal human fMLP receptor 1 (FPR1) was cloned in 1990 from a differentiated HL-60 myeloid leukemia cell cDNA library.
PANARO, Maria Antonietta +5 more
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Adaptive Evolution of Formyl Peptide Receptors in Mammals
Journal of Molecular Evolution, 2015The formyl peptide receptors (FPRs) are a family of chemoattractant receptors with important roles in host defense and the regulation of inflammatory reactions. In humans, three FPR paralogs have been identified (FPR1, FPR2, and FPR3) and may have functionally diversified by gene duplication and adaptive evolution.
Yoshinori, Muto +4 more
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Formyl-Peptide Receptors in Infection, Inflammation, and Cancer
Trends in Immunology, 2018Formyl-peptide receptors (FPRs) recognize bacterial and mitochondrial formylated peptides as well as endogenous non-formylated peptides and even lipids. FPRs are expressed on various host cell types but most strongly on neutrophils and macrophages. After the discovery of FPRs on leukocytes, it was assumed that these receptors predominantly govern a ...
Elisabeth, Weiß, Dorothee, Kretschmer
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1999
The chemotaxis of phagocytic leukocytes from the blood to tissues identifies the acute (neutrophil) and chronic (macrophages) inflammatory condition (1). This hallmark process is central to host defense against microorganisms, to mediation of the immune response, and to repair of injured tissues. When unregulated, however, it is also the key vehicle of
John S. Mills +3 more
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The chemotaxis of phagocytic leukocytes from the blood to tissues identifies the acute (neutrophil) and chronic (macrophages) inflammatory condition (1). This hallmark process is central to host defense against microorganisms, to mediation of the immune response, and to repair of injured tissues. When unregulated, however, it is also the key vehicle of
John S. Mills +3 more
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The Uncoupled State of the Human Formyl Peptide Receptor
Journal of Receptors and Signal Transduction, 1999The formyl peptide receptor (FPR) has been widely used to study the kinetics of the interaction between ligand, receptor and G protein with real-time fluorescence methods. Because the wild type receptor rapidly signals, and is then desensitized and internalized once occupied by ligand, it has been difficult to study the uncoupled receptor form. We have
T L, Gilbert, E R, Prossnitz, L A, Sklar
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Receptors for chemotactic formyl peptides as pharmacological targets
International Immunopharmacology, 2002Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes.
Yingying, Le +6 more
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Differential Activation of Formyl Peptide Receptor Signaling by Peptide Ligands
Molecular Pharmacology, 2003Formyl peptide receptor (FPR) and formyl peptide receptor like 1 (FPRL1) play important roles in inflammation and immunity. Stimulation of FPR and FPRL1 initiates a cascade of signaling events, leading to activation of various phagocyte responses, including chemotaxis, superoxide generation, and exocytosis.
Bae, Yoe-Sik +7 more
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Formyl Peptide Chemotactic Receptors of Leukocytes and Macrophages
1980Publisher Summary Polymorphonuclear leukocytes, monocytes, and macrophages play a central role in host defence against invading microorganisms. However, the killing mechanisms employed by these motile cells are effective over short distances and require intimate cell-microorganism contact. A mechanism for ensuring efficient accumulation of phagocytic
J E, Niedel, P, Cuatrecasas
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Epigenetic regulation of the formyl peptide receptor 2 gene
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016Lipoxin (LX) A4, a main stop signal of inflammation, exerts potent bioactions by activating a specific G protein-coupled receptor, termed formyl peptide receptor 2 and recently renamed ALX/FPR2. Knowledge of the regulatory mechanisms that drive ALX/FPR2 gene expression is key for the development of innovative anti-inflammatory pharmacology.
SIMIELE, FELICE +6 more
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