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Conformational Aspects of Human Formyl-peptide Receptor Agonists
Arzneimittelforschung, 2011The conformation of several Met-Ile-Phe-Leu analogues was analyzed using circular dichroism and infra-red absorption. Their effect on human neutrophils was verified by receptor binding assays and measurements of lysozyme release. The results demonstrate that in amphipatic environments the compounds examined can be highly and weakly ordered in beta-turn
DALPIAZ, Alessandro +5 more
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Molecular biology for formyl peptide receptors in human diseases
Journal of Molecular Medicine, 2013Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. The first chemotactic factors structurally defined were N-formyl peptides. Subsequently, numerous ligands were identified to activate formyl peptide receptors (FPRs) that belong to the seven-transmembrane G protein-coupled ...
Yongsheng, Li, Duyun, Ye
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Targeting formyl peptide receptors to facilitate the resolution of inflammation
European Journal of Pharmacology, 2018The formyl peptide receptors (FPRs) are G protein coupled receptors that recognize a broad range of structurally distinct pathogen and danger-associated molecular patterns and mediate host defense to infection and tissue injury. It became evident that the cellular distribution and biological functions of FPRs extend beyond myeloid cells and governing ...
János G, Filep +2 more
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C5a and formyl peptide receptor regulation on human monocytes
Journal of Leukocyte Biology, 1992Abstract Regulation of C5a and formyl-methionine-leucine-phenylalanine-lysine (fMLPL) receptors on human monocytes has been studied using fluorescein-conjugated derivatives and flow cytometry. Monocytes have receptors for each of these ligands, as evidenced by their ability to bind specifically biologically active fluorescein derivatives
D E, Van Epps +2 more
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The Formyl Peptide Chemotactic Receptor: Cellular Processing of Peptide and Receptor
1983An integrated series of complex cellular functions of polymorphonuclear leukocytes, monocytes and macrophages comprise the inflammatory response. After recognition of an inflammatory stimulus, these phagocytic cells become adherent, migrate in a directed manner through the blood vessel wall and/or the tissue space, ingest opsonized particulate material,
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Vomeronasal Formyl Peptide Receptors in mammals
2016This thesis uncovers the genetic accidents that led to the acquisition of Formyl Peptide Receptor gene expression in the vomeronasal system of a rodent lineage that represents about 23% of the mammalian species. We also examined whether the cluster organization of vomeronasal genes is involved in the regulation of their expression with the presence of ...
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Formyl peptide receptors as therapeutic targets in eye disease
Trends in Pharmacological SciencesOnce known only as immune sentinels, formyl peptide receptors (FPRs) have emerged as paradoxical regulators of ocular health, capable of driving injury or repair in a ligand-dependent manner. We discuss FPR signaling in diabetic retinopathy, dry eye disease, and retinitis pigmentosa, highlighting therapeutic opportunities arising from biased receptor ...
Rafael André, da Silva +4 more
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Cellular Processing of the Formyl Peptide Receptor
1983J E, Niedel, B L, Dolmatch
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Structural and conformational studies of biased agonism through formyl peptide receptors
American Journal of Physiology - Cell Physiology, 2022Richard Ye
exaly