Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene [PDF]
Advanced ScienceChanges in the composition of specific cell‐surface molecules on immune cells are important early markers of directed immune responses. Current biosensors largely focus on detecting soluble disease markers.
Ahmar Hasnain +5 more
doaj +3 more sources
The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction [PDF]
Neural Regeneration Research, 2020 N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family.
Peter J.G. Cussell +3 more
doaj +2 more sources
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition [PDF]
Molecules, 2017 The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide ...
Hui-Qiong He, Richard D. Ye
doaj +2 more sources
The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease [PDF]
Frontiers in ImmunologyPattern Recognition Receptors (PRRs) are a superfamily of receptors that detect molecular structures typical for pathogens and damaged cells and play a crucial role in the proper function of the innate immune system.
Filomena Napolitano +2 more
doaj +2 more sources
Fragments of viral surface proteins modulate innate immune responses via formyl peptide receptors [PDF]
iScienceSummary: Formyl peptide receptors (FPRs) are pattern recognition receptors well-known for bacterial pathogen sensing. We here identified activator and inhibitor motifs for FPRs that are present on surface proteins of various viral pathogens.
Heiko Heilmann +7 more
doaj +2 more sources
Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease [PDF]
Journal of Neuroinflammation, 2020 Background An important hallmark of Alzheimer’s disease (AD) is the increase of Aβ1-42 burden and its accumulation to senile plaques, leading the reactive gliosis and neurodegeneration.
Nicole Schröder +15 more
doaj +2 more sources
Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases [PDF]
MoleculesIn physiological situations involving cell damage, molecules derived from mitochondria or bacteria are produced. These molecules are known as N-formyl peptides and are detected by formyl peptide receptors (FPRs), which stimulate immune cells to migrate ...
Livia Alvarenga +5 more
doaj +2 more sources
Functional characterization of three mouse formyl peptide receptors. [PDF]
Mol Pharmacol, 2013 The evolutionary relationship and functional correlation between human formyl peptide receptors (FPRs) and their mouse counterparts remain incompletely understood. We examined three members of the mouse formyl peptide receptor subfamily (mFprs) and found that they differ in agonist preference and cellular distributions.
He HQ +6 more
europepmc +4 more sources
The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer [PDF]
Technology in Cancer Research & Treatment, 2020 Chronic inflammation is a causative factor of many cancers, although it originally acts as a protective host response to the loss of tissue homeostasis. Many inflammatory conditions predispose susceptible cells, most of which are of epithelial origin, to
Cuimeng Tian MD +5 more
doaj +2 more sources
Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4 [PDF]
Mediators of Inflammation, 2016 We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte +7 more
doaj +2 more sources