Results 41 to 50 of about 18,956 (211)

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]

, 1990
Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland, Wenzel-Seifert, Katharina   +1 more
core   +1 more source

Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis [PDF]

, 2014
Formyl-peptide receptor type 2 (FPR2; also called ALX because it is the receptor for lipoxin A4) sustains a variety of biological responses relevant to the development and control of inflammation, yet the cellular regulation of this G-protein-coupled ...
Babbin, Bennett, Berthouze, Cao, Chiang, Cooray, Dufton, Ernst, Gage, Gilbert, Gorvel, Hanyaloglu, Hanyaloglu, Hislop, Huet, Kam, Key, Key, Key, Lauffer, Le, Lefkowitz, Levy, Maestes, Maxfield, Nathan, Oakley, Pippig, Potter, Rabiet, Reiter, Revankar, Tanowitz, Temkin, Thompson, Thompson, Thompson, Vargas, Vines, Wagener, Yudowski, Zhang   +41 more
core   +2 more sources

Formyl Peptide Receptor 1 and 2 Dual Agonist Inhibits Human Neutrophil Chemotaxis by the Induction of Chemoattractant Receptor Cross-desensitization

Journal of Pharmacological Sciences, 2011
Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human ...
Yoshitaka Sogawa, Takao Ohyama, Hiroaki Maeda, Kazuki Hirahara   +3 more
doaj   +1 more source

Granulocyte activation by danger signals and blocking of receptor responses [PDF]

, 2007
Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged tissues.
Stenfeldt, Anna-Lena
core   +1 more source

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

JACC: Basic to Translational Science, 2019
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and ...
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD   +22 more
doaj   +1 more source

Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis

OncoImmunology, 2023
Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that is mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated with reduced responses to chemotherapy or chemoradiotherapy.
Le Naour, Julie, Montégut, Léa, Pan, Yuhong, Scuderi, Sarah Adriana, Cordier, Pierre, Joseph, Adrien, Sauvat, Allan, Iebba, Valerio, Paillet, Juliette, Ferrere, Gladys, Brechard, Ludivine, Mulot, Claire, Dubourg, Grégory, Zitvogel, Laurence, Pol, Jonathan, Vacchelli, Erika, Puig, Pierre-Laurent, Kroemer, Guido   +17 more
openaire   +6 more sources

Structural Requirements for Molecular Recognition by fMLP Analogs Receptors: Comparative Conformational Analysis of (for-Met-Leu-Phe- OMe) and its Thioamide Analog (for-Met-Leuψ[CSNH]Phe-OMe)

Acta Chimica Slovenica, 2018
In order to determine the structural requirements of fMLP analogs receptors, this work presents the results of a comparative conformational analysis of the active chemotactic peptide (formyl-Met-Leu-Phe-OMe) and its inactive analog (formyl-Met-Leuψ [CSNH]
Chakib Ameziane Hassani, Mourad Houssat, Jamal Eddine Hazm, Ahmed Harrach   +3 more
doaj   +1 more source

Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils [PDF]

, 2012
It is postulated that peptides derived from the N-terminal region of Annexin A1, a glucocorticoid-regulated 37-kDa protein, could act as biomimetics of the parent protein.
Dalli, J., Montero-Melendez, T., McArthur, S., Perretti, M., Dalli, J., Montero-Melendez, T., McArthur, S., Perretti, M.   +7 more
core   +2 more sources

Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]

, 2016
Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Carriero, Maria V, Danese, Silvio, Fonteyne, Philippe, Genua, Marco, GRIECO, PAOLO, Ingangi, Vincenzo, Malesci, Alberto, MERLINO, FRANCESCO, Piontini, Andrea, YOUSIF, ALI MUNAIM   +9 more
core   +1 more source

A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus [PDF]

, 2008
Background More than 10 members of seven-transmembrane G protein-coupled receptors (GPCRs) have been shown to work as coreceptors for human immunodeficiency virus type 1 (HIV-1), HIV type 2 (HIV-2), and simian immunodeficiency viruses (SIVs). As a common
Nobuaki Shimizu, Atsushi Tanaka, Takahisa Mori, Takahiro Ohtsuki, Aliful Hoque, Atsushi Jinno-Oue, Chatchawann Apichartpiyakul, Shigeru Kusagawa, Yutaka Takebe, Hiroo Hoshino   +9 more
core   +1 more source