Results 41 to 50 of about 57,237 (306)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Current and potential contributions of large-scale food fortification to meeting micronutrient requirements in Senegal: a modelling study using household food consumption data

BMJ Public Health
Introduction Micronutrient deficiencies are common among women of reproductive age (WRA) and children in Senegal. Large-scale food fortification (LSFF) can help fill gaps in dietary intake.Methods We used household food consumption data to model the ...
Katherine P Adams, Reina Engle-Stone, Brent Wibberley, Becky L Tsang, Ann Tarini, Maguette Beye, Laura A Rowe   +6 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

The Impact of a Counseling Program on Enhancing Psychological Capital Among Single-Parent Mothers in Bahrain

Journal of Umm Al-Qura University for Educational and Psychological Sciences
The aim of this study was to evaluate the impact of a counseling program on the development of psychological capital among a sample of mothers from single-parent families in the Kingdom of Bahrain. The study adopted a quasi-experimental design, selecting
Mooza Duaij Al-Ruwaiei
doaj   +1 more source

FACTORS INFLUENCING FOOD FORTIFICATION AS A MEANS TO COMBAT MALNUTRITION AMONG CHILDREN ATTENDING IMMUNIZATION AT NAKASONGOLA HEALTH CENTER IV. A CROSS-SECTIONAL STUDY.

Student's Journal of Health Research Africa, 2023
Introduction:  Objectives: To determine the factors influencing food fortification as a means to combat malnutrition among children attending immunization whereas the specific objectives were to assess the knowledge of caretakers, ascertain the attitude,
Arthur Matthew Bukenya , Justine Negesa
doaj   +1 more source

Ti‐Doping Activates Adjacent Zr Sites in Bimetallic MOFs for Cooperative Phospholipid Removals in Human Biomonitoring

Advanced Science, EarlyView.
Ti‐doped Zr/Ti bimetallic MOFs activate neighboring Zr sites to selectively capture phospholipids from serum through cooperative interactions. In nontargeted screening, the material minimizes matrix interference, expands detectable feature coverage, and enables broad recovery of diverse chemical hazards, providing a powerful cleanup strategy for LC ...
Yanmin Liang, Hongyue Ma, Feier Bai, Jing Zhang, Yan Qi, Bing Shao   +5 more
wiley   +1 more source

Exploring the therapeutic and nutritional potential of camel milk: Challenges and prospects: A comprehensive review

Applied Food Research
Camel milk, often termed ''white gold,'' is an essential nutritional resource for nomadic communities in arid regions, particularly across East and Central Africa.
Soumya Singh, Sonia Mann, Rhythm Kalsi, Shambhavi Singh, Neetu Kumra Taneja, Harinder Singh Oberoi, Komal Chauhan, Pankaj Taneja   +7 more
doaj   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

The nutritional impact of fortified ready-to-eat cereals on the diets of school age children [PDF]

, 2000
Plan BThe Continuing Survey of Food Intakes by Individuals, 1995 data base was used to compare overall nutrient intake of cereal and noncereal eaters age 6 to 17 years-old.
Johnson, Carolyn
core  

Fortification of Vitamin B12 to Flour and the Metabolic Response

, 2011
Vitamin B12 deficiency is a common clinical condition, sometimes leading to severe hematologic and neurologic diseases. Screening for vitamin B12 deficiency is indicated in patients with relevant signs, such as anemia, neuropathy, or cognitive impairment.
Davide Agnoletti, Yi Zhang, Michel E. Safar, Safar M. E., Agnoletti D., Sébastien Czernichow, Czernichow S., Galan P., Pilar Galan, Serge Hercberg, Zhang Y., Jacques Blacher, Hercberg S., Blacher J.   +13 more
core   +1 more source