Results 51 to 60 of about 57,237 (306)

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Status of prevention of neural tube defects post-folic acid fortification of cereal grains in South Africa

Public Health Nutrition
Objective: Neural tube defects (NTD) are serious, life-threatening birth defects. Staple food fortification with folic acid (vitamin B9) is a proven, effective intervention to reduce NTD birth prevalence.
Vijaya Kancherla, Phillip Randall, Arnold L Christianson, Helen Louise Malherbe   +3 more
doaj   +1 more source

The impact of food fortification on stunting in Zimbabwe: does gender of the household head matter?

Nutrition Journal, 2020
Background High prevalence of stunting in children under 5 years poses a major threat to child development in developing countries. It is associated with micronutrient deficiency arising from poor diets fed to children under 5 years.
Terrence Kairiza, George Kembo, Asankha Pallegedara, Lesley Macheka   +3 more
doaj   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Global heterogeneity in folic acid fortification policies and implications for prevention of neural tube defects and stroke: a systematic reviewResearch in context

EClinicalMedicine
Summary: Background: Folic acid (pteroylmonoglutamic acid) supplements are highly effective for prevention of neural tube defects (NTD) prompting implementation of mandatory or voluntary folic acid fortification for prevention of NTDs.
Matthew Quinn, Jim Halsey, Paul Sherliker, Hongchao Pan, Zhengming Chen, Derrick A. Bennett, Robert Clarke   +6 more
doaj   +1 more source

Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts

Journal of Nutrition & Intermediary Metabolism, 2017
Objective: In 2009, Australia implemented mandatory folic acid fortification in wheat flour for bread-making. The primary aim was to improve folate status in reproductive-aged women to reduce neural tube defect incidence.
Emma Louise Beckett, Charlotte Martin, Lyndell Boyd, Teagan Porter, Katrina King, Suzanne Niblett, Zoe Yates, Martin Veysey, Mark Lucock   +8 more
doaj   +1 more source

Sectoral Division of Rapallo Border Defence Systems and Discovering the Extent of the Rupnik Line Fortification System [PDF]

Igra Ustvarjalnosti, 2018
This study focused on improving the understanding of the actual extent and spatial impacts of the Rupnik Line as one of the two fortification systems of the Rapallo Border.
Janez Peter Grom, Petra Štukovnik
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Influence of Curing Time on the Mechanical Behavior of Cold Recycled Bituminous Mix in Flexible Pavement Base Layer

Applied Sciences
This study examined the mechanical behavior characteristics of cold recycled emulsified asphalt bases with RAP 76% and emulsified asphalt 3%, in different cure time, i.e., 0, 7, 14 and 28 days and evaluated in terms of the resilient modulus (RM) and ...
Lisley Madeira Coelho, Rafael Pereira Kox, Antônio Carlos Rodrigues Guimarães, Rafael Travincas, Sergio Neves Monteiro   +4 more
doaj   +1 more source