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Transcriptome analysis of fowl adenovirus serotype 4 infection in chickens [PDF]

Virus Genes, 2019
Fowl adenovirus serotype 4 (FAdV-4) is a causative agent of inclusion body hepatitis and hydropericardium-hepatitis syndrome. These diseases cause considerable economic losses in the global poultry industry and are significant stressors for infected chickens. However, the molecular mechanisms of FAdV-4 pathogenesis are poorly understood. In the present
Miaorong Huang, Han Wang, Yuanyuan Yan   +2 more
exaly   +3 more sources

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The pros and cons of cytokines for fowl adenovirus serotype 4 infection

Archives of Virology, 2021
Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has spread on chicken farms worldwide, causing huge economic losses. Currently, the exact mechanism of pathogenesis of FAdV-4 remains unknown. Despite the severe inflammatory damage observed in chickens infected with pathogenic FAdV-4, few studies have focused on ...
Baiyu Wang, Huifang Guo, Jun Zhao
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An inactivated oil-emulsion fowl Adenovirus serotype 4 vaccine provides broad cross-protection against various serotypes of fowl Adenovirus

Vaccine, 2014
The number of clinical cases of inclusion body hepatitis (IBH) and hydropericardium-hepatitis syndrome (HHS) has been increasing, resulting in considerable economic losses in many countries. Currently, only fowl Adenovirus (FAdV) serotype 4 (FAdV-4) has been reported as the causative agent of HHS, whereas IBH can be caused by all 12 serotypes of FAdV ...
Chang-Seon Song, Dong-Hun Lee, Sungsu Youk   +2 more
exaly   +3 more sources

Pathogenicity and virus shedding ability of fowl adenovirus serotype 4 to ducks

Veterinary Microbiology, 2022
Fowl adenovirus serotype 4 (FAdV-4) is the pathogen causing hepatitis-hydropericardium syndrome (HHS) in broilers. Since June 2015, it has emerged as one of the leading causes of economic losses in the poultry industry in China. Although most studies on FAdV-4 have focused on its pathogenicity to broilers, limited studies have been performed on other ...
Zhihui, Tang, Meng, Liu, Zhangshan, Gao, Mengcong, Li, Jie, Cao, Hongliu, Ye, Suquan, Song, Liping, Yan   +7 more
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Pathogenicity of fowl adenovirus (FAdV) serotype 4 strain SDJN in Taizhou geese

Avian Pathology, 2019
Hydropericardium hepatitis syndrome (HHS) is a fatal disease in chickens, mainly caused by fowl adenovirus serotype 4 (FAdV-4). Since June 2015, HHS has appeared in many provinces in China. The disease has spread from broilers to laying hens, breeders and Cherry Valley ducks, seriously endangering the health of the poultry industry in China.
Yi Tang, Jingdong Hu
exaly   +3 more sources

Characterization of fowl adenovirus serotype 4 circulating in chickens in China

Veterinary Microbiology, 2019
Outbreaks of fowl adenovirus (FAdV) has resulted in huge economic losses in poultry industry in China since 2015. This study detected the pathogens from diseased chickens and determined that fowl adenovirus serotype 4 (FAdV-4) and co-infection of immunosuppressive pathogens were the causes of the outbreaks.
Zhimin, Jiang, Mengda, Liu, Chenxi, Wang, Xiaowei, Zhou, Fangtao, Li, Jingwei, Song, Juan, Pu, Yipeng, Sun, Mingyang, Wang, Muhammad, Shahid, Fanhua, Wei, Honglei, Sun   +11 more
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Immunological and molecular comparison of fowl adenovirus serotypes 4 and 10

Archives of Virology, 1995
Some discussion has centered on whether fowl adenovirus (FAV) serotypes 4 and 10 are distinct serotypes or in fact should be reclassified as a single serotype. We have undertaken a detailed characterisation of representatives of both serotypes in order to determine if types 4 and 10 should be grouped together or retained as distinct serotypes ...
K, Erny, J, Pallister, M, Sheppard
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Fowl Adenovirus Serotype 4 Influences Arginine Metabolism to Benefit Replication

Avian Diseases, 2019
Hydropericardium syndrome (HPS) is caused by fowl adenovirus serotype 4 (FAdV-4). HPS has caused outbreaks in Chinese populations of broiler chickens since 2015. However, little is known about the molecular mechanisms underlying HPS. In this study, we used transcriptomic analysis to screen differentially expressed genes (DEGs) in the livers of FAdV-4 ...
Zhixin, Lin, Ruiling, Huang, Jiaxin, Zhou, Yuan, Chen, Lihui, Xu, Yuyun, Gao, Changkang, Wang, Quanxi, Wang   +7 more
exaly   +3 more sources

Analysis of pathogenicity and immune efficacy of fowl adenovirus serotype 4 isolates

Poultry Science, 2018
In the present study, the pathogenicity of fowl adenovirus (FAdV) serotype 4 strain HB1501 was systematically determined by using different doses and routes of inoculation in chickens and assessed the immune efficacy induced by fowl adenovirus serotype 4 (FAdV-4) strain SB15 in a vaccination trial.
S, Ruan, J, Zhao, Z, He, H, Yang, G, Zhang   +4 more
exaly   +3 more sources

A novel recombinant serotype 4 fowl adenovirus efficiently protects both serotype 4 and 11 fowl adenovirus

Veterinary Microbiology
Recently, the diseases caused by the infection of multiple serotypes of fowl adenoviruses (FAdVs) have spread worldwide and resulted in huge economic losses to the poultry industry. However, the commercial multivalent or bivalent vaccines against different serotypes of FAdV are not available. In this study, a novel recombinant FAdV-4, designated FAdV-4-
Shi, Liu, Ye, Tang, Tuofan, Li, Zhimin, Wan, Hongxia, Shao, Aijian, Qin, Quan, Xie, Wei, Gao, Jianqiang, Ye   +8 more
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