Results 61 to 70 of about 12,816,028 (152)

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

open access: yesAdvanced Sensor Research, Volume 5, Issue 4, April 2026.
Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically examines current therapeutic strategies for sensorineural hearing loss, including traditional drug and physical therapies as well as emerging stem cell and gene therapies, providing a ...
Ruirui Chen   +3 more
wiley   +1 more source

Isolation and molecular characterization of prevalent Fowl adenovirus strains in southwestern China during 2015–2016 for the development of a control strategy

open access: yesEmerging Microbes and Infections, 2017
Fowl adenovirus (FAdV) has caused significant losses in chicken flocks throughout China in recent years. However, the current understanding of the genetic and pathogenic characteristics of the FAdV epidemic in southwestern China remains poorly understood.
Jing Xia   +11 more
doaj   +1 more source

Transcriptome analysis reveals critical factors for survival after adenovirus serotype 4 infection

open access: yesPoultry Science, 2023
: Fowl adenovirus serotype-4 (FAdV-4) is highly lethal to poultry, making it one of the leading causes of economic losses in the poultry industry. However, a small proportion of poultry can survive after FAdV-4 infection.
Yuhang Zhou   +14 more
doaj   +1 more source

Quantitative microbial risk assessment with microbial source tracking for enteric pathogens in southwest Wisconsin private wells

open access: yesJournal of Environmental Quality, Volume 55, Issue 2, March/April 2026.
Abstract Private wells supply drinking water for many households, and their contamination by fecal microbes presents a risk of acute gastrointestinal illness (AGI). Risk is thought to vary by contaminating fecal source, but specific associations with fecal source are unknown for most private wells in the United States. This study characterizes AGI risk
Tucker Burch   +4 more
wiley   +1 more source

Fowl adenovirus serotype 4: Epidemiology, pathogenesis, diagnostic detection, and vaccine strategies

open access: yesPoultry Science, 2017
Fowl adenovirus (FAdV) serotype-4 is highly pathogenic for chickens, especially for broilers aged 3 to 5 wk, and it has emerged as one of the foremost causes of economic losses to the poultry industry in the last 30 years. The liver is a major target organ of FAdV-4 infections, and virus-infected chickens usually show symptoms of hydropericardium ...
P H, Li   +5 more
openaire   +2 more sources

Development of a subunit vaccine based on fiber2 and hexon against fowl adenovirus serotype 4

open access: yesVirus Research, 2021
Hepatitis-hydropericardium syndrome (HHS) is widespread in China and causes high chicken mortality that results in great economic losses. A safe and effective vaccine is needed, and a subunit vaccine has potential for development. In this study, a truncated region of the FAdV-4 fiber 2 fused with coding sequence of one epitope of hexon was expressed in
Jixiong Hu   +8 more
openaire   +2 more sources

Establishment of a chicken challenge model of fowl adenovirus serotype-4 for vaccine verification

open access: yes, 2021
Fowl adenovirus serotype-4 (FAdV-4) infection, also known as hydropericardium-hepatitis syndrome (HHS), is one of the most prevalent diseases in the Korean poultry industry.
I P Mo, Bon-Sang Koo, J Y Kim
core   +1 more source

Bee products as alternatives in the treatment of viral infections

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba   +3 more
wiley   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

open access: yesSmall Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N   +2 more
wiley   +1 more source

Attenuated Infectious Bronchitis Virus (IBV) Vaccination Induces Protective Humoral and Cellular Immunity Against SARS‐CoV‐2 in Mammals

open access: yesJournal of Immunology Research, Volume 2026, Issue 1, 2026.
Occupational exposure to infectious bronchitis virus (IBV) has been associated with cross‐reactivity to other coronaviruses such as SARS‐CoV‐2. In this study, we investigated the immune response of IBV using reconstituted samples of the commercial H120 Mass‐I vaccine (Zoetis) against SARS‐CoV‐2 infection.
Ney de Carvalho Almeida   +20 more
wiley   +1 more source

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