Critical Role of Viral Protein Hexon in Hypervirulent Fowl Adenovirus Serotype-4-Induced Autophagy by Interaction with BAG3 and Promotion of Viral Replication in LMH Cells. [PDF]
HHS, mainly caused by HPFAdV-4, has caused large economic losses to the stakeholders in recent years. Infection of leghorn male hepatocellular (LMH) cells by HPFAdV-4 induced complete autophagy that is essential for HPFAdV-4 replication.
Li W +9 more
europepmc +2 more sources
Molecular characterization and phylogenetic analysis of fowl adenovirus serotype-4 from Guangdong Province, China [PDF]
Aim: Our aim in this study was to isolate potentially novel strains of fowl adenovirus serotype-4 (FAdV-4) that is currently circulating in broiler chicken flocks in Guangdong Province, China, and to compare nucleotide and amino acid (AA) sequences of ...
Fu Yuming +12 more
doaj +2 more sources
Transcriptome Analysis Reveals New Insight of Fowl Adenovirus Serotype 4 Infection [PDF]
Since 2015, Fowl adenovirus serotype 4 (FAdV-4) infection has caused serious economic losses to the poultry industry worldwide. We isolated and identified the FAdV-4 strain NP, from infected chickens on a layer farm, using chicken embryo allantoic cavity
Yuan Chen +11 more
doaj +3 more sources
Development and evaluation of three multienzyme isothermal rapid amplification assays for fowl adenovirus serotype 4. [PDF]
Fowl adenovirus serotype 4 (FAdV-4) is the main causative agent of hydropericardium hepatitis syndrome (HHS), which has resulted in huge economic losses to the poultry industry in recent years.
Dai Y +10 more
europepmc +2 more sources
The Development of a Novel Fiber-2 Subunit Vaccine against Fowl Adenovirus Serotype 4 Formulated with Oil Adjuvants. [PDF]
Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has been widely spread across China, resulting in great financial losses in the poultry industry.
Liu W +6 more
europepmc +2 more sources
Recombinant fiber-1 protein of fowl adenovirus serotype 4 induces high levels of neutralizing antibodies in immunized chickens. [PDF]
Virulent fowl adenovirus serotype 4 (FAdV-4) causes hydropericardium syndrome (HPS) with high mortality in chickens, leading to significant economic losses to the poultry industry.
Watanabe S +5 more
europepmc +2 more sources
Immunoprotection of FliBc chimeric fiber2 fusion proteins targeting dendritic cells against Fowl adenovirus serotype 4 infection. [PDF]
Hepatitis-hydropericardium syndrome (HHS) is a highly fatal disease in chickens caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4), which has severe economic consequences.
Li Y +7 more
europepmc +2 more sources
Research Note: Overview of fowl adenovirus serotype 4: structure, pathogenicity, and progress in vaccine development [PDF]
: Fowl adenovirus serotype 4 (FAdV) is highly pathogenic and lethal to chickens, especially broilers, which has emerged as one of the most important economic losses for the poultry industry in the past few years.
Iman Pouladi +2 more
doaj +2 more sources
Development of a colloidal gold immunochromatographic strip for the rapid detection of fowl adenovirus serotype 4 using prepared penton protein-specific monoclonal antibodies. [PDF]
Fowl adenovirus serotype 4 (FAdV-4) is the primary pathogen responsible for hydropericardium-hepatitis syndrome (HHS) and is associated with high mortality rates (20–80%) in 3–6-week-old chickens.
Luo S +14 more
europepmc +2 more sources
Transcriptome analysis reveals critical factors for survival after adenovirus serotype 4 infection
: Fowl adenovirus serotype-4 (FAdV-4) is highly lethal to poultry, making it one of the leading causes of economic losses in the poultry industry. However, a small proportion of poultry can survive after FAdV-4 infection.
Yuhang Zhou +14 more
doaj +2 more sources

