Results 41 to 50 of about 7,684 (200)

Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W) [PDF]

Oncogene, 2010
Some mutations in FOXL2 result in premature ovarian failure accompanied by blepharophimosis, ptosis, epicanthus inversus syndrome type I disease, and FOXL2-null mice exhibit developmental defects in granulosa cells. Recently, FOXL2 c.402C>G, a new somatic mutation that leads to a p.C134W change, was found in the majority of adult-type ovarian granulosa
J-H, Kim, S, Yoon, M, Park, H-O, Park, J-J, Ko, K, Lee, J, Bae   +6 more
openaire   +2 more sources

FOXL2: a central transcription factor of the ovary [PDF]

Journal of Molecular Endocrinology, 2013
Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are responsible for the blepharophimosis ptosis epicanthus inversus syndrome, which includes eyelid and mild craniofacial defects associated with primary ovarian insufficiency ...
Georges, Adrien, Auguste, Aurelie, Bessière, Laurianne, Vanet, Anne, Todeschini, Anne-Laure, Veitia, Reiner A   +5 more
openaire   +3 more sources

Foxl2 is required for commitment to ovary differentiation [PDF]

Human Molecular Genetics, 2005
Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination.
Chris Ottolenghi, Shakib Omari, J Elias GarciaOrtiz, Manuela Uda, Laura Crisponi, Antonino Forabosco, Giuseppe Pilia, David Schlessinger   +7 more
openaire   +4 more sources

Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium

Reproductive Biology and Endocrinology, 2018
Background Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its levels fluctuate during pregnancy.
Michal Elbaz, Ron Hadas, Louise M. Bilezikjian, Eran Gershon   +3 more
doaj   +1 more source

Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells [PDF]

, 2016
Primary sex determination in placental mammals is a very well studied developmental process. Here, we aim to investigate the currently established scenario and to assess its adequacy to fully recover the observed phenotypes, in the wild type and ...
Chaouiya, Claudine, Sánchez, Lucas
core   +2 more sources

Oocytes suppress FOXL2 expression in cumulus cells in mice† [PDF]

Biology of Reproduction, 2020
Abstract Cumulus cells and mural granulosa cells (MGCs) play distinct roles during follicular development, and normal development of these cell lineages is critical for the female fertility. Transcriptomic diversification between the two cell lineages is obviously a critical mechanism for their functional diversification; however, the ...
Chihiro, Emori, Haruka, Ito, Wataru, Fujii, Kunihiko, Naito, Koji, Sugiura   +4 more
openaire   +2 more sources

Expression and localization of forkhead transcriptional factor 2 (Foxl2) in the gonads of protogynous wrasse, Halichoeres trimaculatus

Biology of Sex Differences, 2010
Background Three-spot wrasse, Halichoeres trimaculatus, is a marine protogynous hermaphrodite fish. Individuals mature either as initial phase (IP) males or females. Appropriate social cues induce the sex change from IP female to terminal phase (TP) male.
Kobayashi Yasuhisa, Horiguchi Ryo, Nozu Ryo, Nakamura Masaru   +3 more
doaj   +1 more source

Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients With FOXL2 Mutations

Frontiers in Endocrinology, 2022
ObjectiveTo characterize the status of ovarian reserve and ART outcomes in BPES women and provide informative reference for clinical diagnosis and treatment.MethodsTwenty-one women with BPES were screened for mutations in the FOXL2 gene and underwent ...
Tingting Meng, Tingting Meng, Tingting Meng, Tingting Meng, Tingting Meng, Wenzhe Zhang, Wenzhe Zhang, Wenzhe Zhang, Wenzhe Zhang, Wenzhe Zhang, Rongrong Zhang, Rongrong Zhang, Rongrong Zhang, Rongrong Zhang, Rongrong Zhang, Jie Li, Jie Li, Jie Li, Jie Li, Jie Li, Yuan Gao, Yuan Gao, Yuan Gao, Yuan Gao, Yuan Gao, Yingying Qin, Yingying Qin, Yingying Qin, Yingying Qin, Yingying Qin, Xue Jiao, Xue Jiao, Xue Jiao, Xue Jiao, Xue Jiao, Xue Jiao   +35 more
doaj   +1 more source

Advances in non-germ cell tumours of the testis: focus on new molecular developments in sex cord-stromal tumours. [PDF]

Histopathology
In this review, we summarise the major recent advances in Testicular Sex Cord‐Stromal Tumours, focusing on molecular alterations and biomarkers relevant for diagnosis, classification and prognosis. Testicular sex cord‐stromal tumours (TSCSTs) represent ~4%–8% of all testicular neoplasms.
Lobo J, Acosta AM.
europepmc   +2 more sources

Lacrimal Gland Involvement in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome [PDF]

, 2016
PURPOSE: To describe the involvement of the lacrimal gland (LG) in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). DESIGN: Observational, cross-sectional study.
A v Cruz, A, Akaishi, P, Araujo Silva, W, Chodraui-Filho, S, Cintra, M, Duarte, AF, Molfetta, G, Toscano, A   +7 more
core   +1 more source