Results 11 to 20 of about 74,948 (336)
Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression
Indian Dermatology Online JournalBackground: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O ...
Parul Kamboj +5 more
doaj +3 more sources
Dermato-Endocrinology, 2011 Oral isotretinoin (13-cis retinoic acid) is the most effective drug in the treatment of acne and restores all major pathogenetic factors of acne vulgaris. isotretinoin is regarded as a prodrug which after isomerizisation to all-trans-retinoic acid (ATRA) induces apoptosis in cells cultured from human sebaceous glands, meibomian glands, neuroblastoma ...
Bodo C. Melnik
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Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs [PDF]
PLOS Genetics, 2021 The hallmarks of the alveolar subclass of rhabdomyosarcoma are chromosomal translocations that generate chimeric PAX3-FOXO1 or PAX7-FOXO1 transcription factors. Overexpression of either PAX-FOXO1s results in related cell transformation in animal models.
Line Manceau +5 more
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MicroRNA-486-5p suppresses inflammatory response by targeting FOXO1 in MSU-treated macrophages
Autoimmunity, 2022 Gouty arthritis (GA) is mainly caused by the precipitation of monosodium urate (MSU) crystals in the joint. Recently, different regulatory roles of microRNAs (miRNAs) in arthritis have been widely verified. Nevertheless, the specific function of microRNA-
Jianguo Hu +6 more
doaj +1 more source
Cell Death and Disease, 2023 Background Hepatic ischemia-reperfusion injury (IRI) is considered as an effecting factor for hepatocellular carcinoma (HCC) recurrence. Th17/Treg cells are a pair of essential components in adaptive immune response in liver IRI, and forkhead box O1 ...
Haozhen Ren +10 more
semanticscholar +1 more source
Reciprocal regulation of hepatic TGF-β1 and Foxo1 controls gluconeogenesis and energy expenditure.
Diabetes, 2023 Obesity and insulin resistance are risk factors for the pathogenesis of T2D. Here we report that hepatic TGF-β1 expression positively correlates with obesity and insulin resistance in mice and humans.
Quan Pan +9 more
semanticscholar +1 more source
Nature Communications, 2021 Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF.
G. Schiattarella +20 more
semanticscholar +1 more source
FoxO1 breaks diabetic heart [PDF]
Journal of Diabetes Investigation, 2012 The incidence of type 2 diabetes is increasing explosively around the world. Both hyperglycemia and insulin resistance can cause myocardial damages with coronary atherosclerosis in type 2 diabetes. In addition, some patients show cardiac functional disorder, characterized by diastolic dysfunction, without ischemia.
Nagao, Mototsugu +2 more
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Theranostics, 2021 Rationale: The rennin-angiotensin-aldosterone system (RAAS) plays a critical role in the pathogenesis of diabetic cardiomyopathy, but the role of a member of RAAS, angiotensin IV (Ang IV), in this disease and its underlying mechanism are unclear.
Meng Zhang +10 more
semanticscholar +1 more source
FoxO1 in embryonic development [PDF]
Transcription, 2012 Establishment of the maternal-fetal circulation during embryonic development is a fundamental process required for effective exchange of nutrients, waste products and signaling factors critical to all subsequent stages of fetal growth and development.
Anwarul, Ferdous, Joseph A, Hill
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